Literature DB >> 28630079

What Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination? Lessons from the Antibody Response to HIV-1.

Gabriel D Victora1, Hugo Mouquet2,3.   

Abstract

Most broadly neutralizing antibodies to HIV-1 have in common an extreme degree of somatic hypermutation (SHM), which correlates with their ability to neutralize multiple viral strains. However, achieving such extreme SHM by immunization remains a challenge. Here, we discuss how antigenic variation during HIV-1 infection may work to exacerbate SHM by permitting multiple iterative cycles of affinity maturation in germinal centers, and speculate on how this could be recapitulated through vaccination.
Copyright © 2018 Cold Spring Harbor Laboratory Press; all rights reserved.

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Year:  2018        PMID： 28630079      PMCID： PMC5932586          DOI： 10.1101/cshperspect.a029389

Source DB:  PubMed          Journal:  Cold Spring Harb Perspect Biol        ISSN： 1943-0264            Impact factor:   10.005


  47 in total

1.  Visualizing antibody affinity maturation in germinal centers.

Authors:  Jeroen M J Tas; Luka Mesin; Giulia Pasqual; Sasha Targ; Johanne T Jacobsen; Yasuko M Mano; Casie S Chen; Jean-Claude Weill; Claude-Agnès Reynaud; Edward P Browne; Michael Meyer-Hermann; Gabriel D Victora
Journal:  Science       Date:  2016-02-18       Impact factor: 47.728

Review 2.  Do Memory B Cells Form Secondary Germinal Centers? It Depends.

Authors:  Kathryn A Pape; Marc K Jenkins
Journal:  Cold Spring Harb Perspect Biol       Date:  2018-01-02       Impact factor: 10.005

3.  Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization.

Authors:  Florian Klein; Ron Diskin; Johannes F Scheid; Christian Gaebler; Hugo Mouquet; Ivelin S Georgiev; Marie Pancera; Tongqing Zhou; Reha-Baris Incesu; Brooks Zhongzheng Fu; Priyanthi N P Gnanapragasam; Thiago Y Oliveira; Michael S Seaman; Peter D Kwong; Pamela J Bjorkman; Michel C Nussenzweig
Journal:  Cell       Date:  2013-03-28       Impact factor: 41.582

4.  HUMORAL IMMUNITY. T cell help controls the speed of the cell cycle in germinal center B cells.

Authors:  Alexander D Gitlin; Christian T Mayer; Thiago Y Oliveira; Ziv Shulman; Mathew J K Jones; Amnon Koren; Michel C Nussenzweig
Journal:  Science       Date:  2015-07-16       Impact factor: 47.728

5.  HIV antibodies. Antigen modification regulates competition of broad and narrow neutralizing HIV antibodies.

Authors:  Andrew T McGuire; Anita M Dreyer; Sara Carbonetti; Adriana Lippy; Jolene Glenn; Johannes F Scheid; Hugo Mouquet; Leonidas Stamatatos
Journal:  Science       Date:  2014-12-12       Impact factor: 47.728

6.  Expansion of HIV-specific T follicular helper cells in chronic HIV infection.

Authors:  Madelene Lindqvist; Jan van Lunzen; Damien Z Soghoian; Bjorn D Kuhl; Srinika Ranasinghe; Gregory Kranias; Michael D Flanders; Samuel Cutler; Naomi Yudanin; Matthias I Muller; Isaiah Davis; Donna Farber; Philip Hartjen; Friedrich Haag; Galit Alter; Julian Schulze zur Wiesch; Hendrik Streeck
Journal:  J Clin Invest       Date:  2012-08-27       Impact factor: 14.808

Review 7.  Emerging concepts on T follicular helper cell dynamics in HIV infection.

Authors:  Franco Pissani; Hendrik Streeck
Journal:  Trends Immunol       Date:  2014-04-02       Impact factor: 16.687

8.  Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice.

Authors:  Pia Dosenovic; Lotta von Boehmer; Amelia Escolano; Joseph Jardine; Natalia T Freund; Alexander D Gitlin; Andrew T McGuire; Daniel W Kulp; Thiago Oliveira; Louise Scharf; John Pietzsch; Matthew D Gray; Albert Cupo; Marit J van Gils; Kai-Hui Yao; Cassie Liu; Anna Gazumyan; Michael S Seaman; Pamela J Björkman; Rogier W Sanders; John P Moore; Leonidas Stamatatos; William R Schief; Michel C Nussenzweig
Journal:  Cell       Date:  2015-06-18       Impact factor: 41.582

9.  Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires.

Authors:  Ming Tian; Cheng Cheng; Xuejun Chen; Hongying Duan; Hwei-Ling Cheng; Mai Dao; Zizhang Sheng; Michael Kimble; Lingshu Wang; Sherry Lin; Stephen D Schmidt; Zhou Du; M Gordon Joyce; Yiwei Chen; Brandon J DeKosky; Yimin Chen; Erica Normandin; Elizabeth Cantor; Rita E Chen; Nicole A Doria-Rose; Yi Zhang; Wei Shi; Wing-Pui Kong; Misook Choe; Amy R Henry; Farida Laboune; Ivelin S Georgiev; Pei-Yi Huang; Suvi Jain; Andrew T McGuire; Eric Georgeson; Sergey Menis; Daniel C Douek; William R Schief; Leonidas Stamatatos; Peter D Kwong; Lawrence Shapiro; Barton F Haynes; John R Mascola; Frederick W Alt
Journal:  Cell       Date:  2016-09-08       Impact factor: 41.582

10.  Host-Pathogen Coevolution and the Emergence of Broadly Neutralizing Antibodies in Chronic Infections.

Authors:  Armita Nourmohammad; Jakub Otwinowski; Joshua B Plotkin
Journal:  PLoS Genet       Date:  2016-07-21       Impact factor: 5.917
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  12 in total

1.  Optimizing immunization protocols to elicit broadly neutralizing antibodies.

Authors:  Kayla G Sprenger; Joy E Louveau; Pranav M Murugan; Arup K Chakraborty
Journal:  Proc Natl Acad Sci U S A       Date:  2020-08-03       Impact factor: 11.205

Review 2.  Affinity war: forging immunoglobulin repertoires.

Authors:  Teng Zuo; Avneesh Gautam; Duane R Wesemann
Journal:  Curr Opin Immunol       Date:  2019-01-25       Impact factor: 7.486

3.  Quantitative modeling of the effect of antigen dosage on B-cell affinity distributions in maturating germinal centers.

Authors:  Simona Cocco; Rémi Monasson; Marco Molari; Klaus Eyer; Jean Baudry
Journal:  Elife       Date:  2020-06-15       Impact factor: 8.140

4.  Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers.

Authors:  Luis M Molinos-Albert; Valérie Lorin; Valérie Monceaux; Sylvie Orr; Asma Essat; Jérémy Dufloo; Olivier Schwartz; Christine Rouzioux; Laurence Meyer; Laurent Hocqueloux; Asier Sáez-Cirión; Hugo Mouquet
Journal:  Nat Commun       Date:  2022-04-11       Impact factor: 14.919

5.  Human Immunodeficiency Virus Tat Protein Aids V Region Somatic Hypermutation in Human B Cells.

Authors:  Xiaohua Wang; Zhi Duan; Guojun Yu; Manxia Fan; Matthew D Scharff
Journal:  mBio       Date:  2018-04-17       Impact factor: 7.867

6.  Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity.

Authors:  Julie Prigent; Annaëlle Jarossay; Cyril Planchais; Caroline Eden; Jérémy Dufloo; Ayrin Kök; Valérie Lorin; Oxana Vratskikh; Thérèse Couderc; Timothée Bruel; Olivier Schwartz; Michael S Seaman; Oliver Ohlenschläger; Jordan D Dimitrov; Hugo Mouquet
Journal:  Cell Rep       Date:  2018-05-29       Impact factor: 9.423

Review 7.  The expanding array of HIV broadly neutralizing antibodies.

Authors:  Laura E McCoy
Journal:  Retrovirology       Date:  2018-10-16       Impact factor: 4.602

Review 8.  Update on Fc-Mediated Antibody Functions Against HIV-1 Beyond Neutralization.

Authors:  Bin Su; Stefania Dispinseri; Valeria Iannone; Tong Zhang; Hao Wu; Raphael Carapito; Seiamak Bahram; Gabriella Scarlatti; Christiane Moog
Journal:  Front Immunol       Date:  2019-12-18       Impact factor: 7.561

9.  Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells.

Authors:  Juhee Pae; Jonatan Ersching; Tiago B R Castro; Marta Schips; Luka Mesin; Samuel J Allon; Jose Ordovas-Montanes; Coraline Mlynarczyk; Ari Melnick; Alejo Efeyan; Alex K Shalek; Michael Meyer-Hermann; Gabriel D Victora
Journal:  J Exp Med       Date:  2021-04-05       Impact factor: 14.307

10.  B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models.

Authors:  Deli Huang; Robert K Abbott; Colin Havenar-Daughton; Patrick D Skog; Rita Al-Kolla; Bettina Groschel; Tanya R Blane; Sergey Menis; Jenny Tuyet Tran; Theresa C Thinnes; Sabrina A Volpi; Alessia Liguori; Torben Schiffner; Sophia M Villegas; Oleksandr Kalyuzhniy; Mark Pintea; James E Voss; Nicole Phelps; Ryan Tingle; Alberto R Rodriguez; Greg Martin; Sergey Kupryianov; Allan deCamp; William R Schief; David Nemazee; Shane Crotty
Journal:  Proc Natl Acad Sci U S A       Date:  2020-09-01       Impact factor: 12.779
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