Literature DB >> 2862939

Synergistic interaction between histamine and ouabain on ventricular fibrillation threshold.

J P Trzeciakowski.   

Abstract

The interaction between histamine and ouabain on the ventricular fibrillation threshold (VFT) was studied in the isolated, Langendorff-perfused heart of the guinea-pig. When administered separately, histamine and ouabain each reduced the VFT in a concentration-related manner with ED50 values of 84.3 and 250 nM, respectively. When perfused in combination the effects of these two drugs on VFT were significantly greater than the sum of their individual contributions. Mepyramine and cimetidine both antagonized the fibrillatory effects of the histamine-ouabain combination. Neither antagonist affected the fibrillation concentration-response curve for ouabain. These results suggest that both classes of histamine receptor may participate in the histamine-ouabain interaction.

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Year:  1985        PMID： 2862939      PMCID： PMC1916752          DOI： 10.1111/j.1476-5381.1985.tb08826.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  32 in total

1.  Toxic effects of ouabain on Purkinje fibers and ventricular muscle fibers.

Authors:  M VASSALLE; J KARIS; B F HOFFMAN
Journal:  Am J Physiol       Date:  1962-09

2.  Effects of calcium ions and local anesthetics on electrical properties of Purkinje fibres.

Authors:  S WEIDMANN
Journal:  J Physiol       Date:  1955-09-28       Impact factor: 5.182

3.  Mechanisms of digitalis toxicity. Effects of ouabain on phase four of canine Purkinje fiber transmembrane potentials.

Authors:  M R Rosen; H Gelband; C Merker; B F Hoffman
Journal:  Circulation       Date:  1973-04       Impact factor: 29.690

Review 4.  Methods for the detection and assessment of antiarrhythmic activity.

Authors:  E Winslow
Journal:  Pharmacol Ther       Date:  1984       Impact factor: 12.310

5.  Release of autonomic neuromediators by local ventricular electrical stimulation.

Authors:  D E Euler
Journal:  Am J Physiol       Date:  1980-06

6.  Quantitative estimation of overadditive and underadditive drug effects by means of theoretical, additive dose-response curves.

Authors:  G Pöch; S Holzmann
Journal:  J Pharmacol Methods       Date:  1980-09

7.  The effects of a benzotriazinium salt on ventricular fibrillation in the guinea-pig perfused isolated heart [proceedings].

Authors:  A M French; N C Scott
Journal:  Br J Pharmacol       Date:  1978-06       Impact factor: 8.739

8.  Reduction of ventricular fibrillation threshold by histamine: resolution into separate H1- and H2-mediated components.

Authors:  J P Trzeciakowski; R Levi
Journal:  J Pharmacol Exp Ther       Date:  1982-12       Impact factor: 4.030

9.  Ventricular arrhythmias in cardiac anaphylaxis.

Authors:  J Senges; U Randolf; H Katus
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-11       Impact factor: 3.000

10.  Comparative antidysrhythmic and haemodynamic effects of orally or intravenously administered mexiletine and ORG 6001 in the anaesthetized rat.

Authors:  R J Marshall; A W Muir; E Winslow
Journal:  Br J Pharmacol       Date:  1981-10       Impact factor: 8.739
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