Adam Sorenson1, Kyle Hresko1, Seth Butcher1, Sean Pierce2, Vinicius Tramontina3, Rosalia Leonardi4, Carla Loreto5, Jose Bosio6, Luis Eduardo Almeida1. 1. a Surgical Sciences Department, Oral Surgery , School of Dentistry, Marquette University , Milwaukee , WI , USA. 2. b OMFS Department , School of Dentistry, University of California, Los Angeles (UCLA) , Los Angeles , CA , USA. 3. c Periodontic Department , School of Dentistry, Pontificia Universidade Catolica do Parana , Curitiba , Brazil. 4. d Orthodontic Department , School of Dentistry, Catania University , Catania , Italy. 5. e Anatomy Department , School of Medicine, Catania University , Catania , Italy. 6. f Orthodontic Department , School of Dentistry, University of Maryland , Baltimore , MD , USA.
Abstract
OBJECTIVE: Temporomandibular disorders (TMD) are a group of conditions affecting the temporomandibular joint (TMJ), leading to jaw dysfunction, joint and muscle pain, and a decrease in quality of life. A communication network of pro- and anti-inflammatory mediators called cytokines maintains the homeostasis of the TMJ. This review will focus on the Interleukin (IL) family of cytokines, which have been quantified in TMJ synovial fluids in a variety of studies. IL-1α and IL-1β have pro-inflammatory effects, while the endogenous receptor antagonist (IL-1RA) inhibits the pro-inflammatory effects of IL-1. METHODS: A literature search (2006-2016) to identify eligible studies was completed using the PubMed database. Studies identified used saline irrigation to quantify cytokine profiles in synovial fluid of healthy and/or dysfunctional joints. RESULTS: The initial search yielded 111 articles, 5 of which met the inclusion criteria after inter-reviewer discussion. CONCLUSIONS: Articles that compared IL-1 concentrations in TMD vs. control groups found significant differences.
OBJECTIVE:Temporomandibular disorders (TMD) are a group of conditions affecting the temporomandibular joint (TMJ), leading to jaw dysfunction, joint and muscle pain, and a decrease in quality of life. A communication network of pro- and anti-inflammatory mediators called cytokines maintains the homeostasis of the TMJ. This review will focus on the Interleukin (IL) family of cytokines, which have been quantified in TMJ synovial fluids in a variety of studies. IL-1α and IL-1β have pro-inflammatory effects, while the endogenous receptor antagonist (IL-1RA) inhibits the pro-inflammatory effects of IL-1. METHODS: A literature search (2006-2016) to identify eligible studies was completed using the PubMed database. Studies identified used saline irrigation to quantify cytokine profiles in synovial fluid of healthy and/or dysfunctional joints. RESULTS: The initial search yielded 111 articles, 5 of which met the inclusion criteria after inter-reviewer discussion. CONCLUSIONS: Articles that compared IL-1 concentrations in TMD vs. control groups found significant differences.
Authors: Abdalwhab Zwiri; Mohammad A I Al-Hatamleh; Wan Muhamad Amir W Ahmad; Jawaad Ahmed Asif; Suan Phaik Khoo; Adam Husein; Zuryati Ab-Ghani; Nur Karyatee Kassim Journal: Diagnostics (Basel) Date: 2020-05-15