Hanna Toorell1, Henrik Zetterberg2,3,4, Kaj Blennow2,3, Karin Sävman5, Henrik Hagberg1,6. 1. a Perinatal Center, Institute of Clinical Sciences, University of Gothenburg, Sahlgrenska University Hospital , Gothenburg , Sweden. 2. b Clinical Neurochemistry Laboratory , Mölndal , Sweden. 3. c Department of Psychiatry and Neurochemistry , Institute of Neuroscience and Physiology , Mölndal , Sweden. 4. d Department of Molecular Neuroscience , UCL Institute of Neurology, University College London , London , UK. 5. e Department of Pediatrics , Institute of Clinical Sciences, University of Gothenburg , Gothenburg , Sweden. 6. f Centre for the Developing Brain, Division of Imaging Sciences and Biomedical Engineering , King's College London, St. Thomas' Hospital , London , UK.
Abstract
AIM: Compare the levels of the brain injury biomarkers Tau and neurofilament light protein (NFL) in cases of asphyxia with those in controls. MATERIALS AND METHODS: We analyzed the neuronal proteins Tau and NFL in umbilical blood of 10 cases of severe-moderate intrapartum asphyxia and in 18 control cases. RESULTS: The levels of both Tau and neurofilament were significantly higher after asphyxia and it appeared to be a correlation between the levels of the biomarkers and the severity of the insult. DISCUSSION: Future studies are warranted to support or refute the value of Tau/NFLin clinical practice. CONCLUSION: Fetal asphyxia remains a clinical problem resulting in life-long neurological disabilities. We urgently need more accurate early predictive markers to direct the clinician when to provide neuroprotective therapy.
AIM: Compare the levels of the brain injury biomarkers Tau and neurofilament light protein (NFL) in cases of asphyxia with those in controls. MATERIALS AND METHODS: We analyzed the neuronal proteins Tau and NFL in umbilical blood of 10 cases of severe-moderate intrapartum asphyxia and in 18 control cases. RESULTS: The levels of both Tau and neurofilament were significantly higher after asphyxia and it appeared to be a correlation between the levels of the biomarkers and the severity of the insult. DISCUSSION: Future studies are warranted to support or refute the value of Tau/NFLin clinical practice. CONCLUSION:Fetal asphyxia remains a clinical problem resulting in life-long neurological disabilities. We urgently need more accurate early predictive markers to direct the clinician when to provide neuroprotective therapy.
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