Literature DB >> 28629088

Encapsulation of methotrexate and cyclophosphamide in interpolymer complexes formed between poly acrylic acid and poly ethylene glycol on multi-walled carbon nanotubes as drug delivery systems.

Mohammad Hossein Ahmadi Azqhandi1, Bahman Vasheghani Farahani2, Nasibe Dehghani2.   

Abstract

By combining the advantage of multi-walled carbon nanotubes (MWCNTs) and interpolymer complexes, we synthesis a new carrier system consist of poly(acrylic acid)/poly(ethylene glycol)/carbon nanotube (PAA/PEG/CNT). Then, Methotrexate (MTX) and Cyclophosphamide (CPP) were loaded on PAA/PEG/CNT, and the physicochemical properties of nanoparticles characterized by Infrared spectroscopy (IR), Scanning Electron Microscopy (SEM), Thermo Gravimetric Analysis (TGA) and Nuclear Magnetic Resonance (NMR). In the second part after efficiency determination of loaded drugs, in vitro drug release study was examined with ultra violet spectroscopy (UV) in pH=7.4 buffer (human body range) and pH=4 buffer (pH of cancer cells), and fever temperature drug release kinetic was studied by different mathematical models.
Copyright © 2017 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Cyclophosphamide; Drug delivery; Inter polymer complexes; Methotrexate; Multi-walled carbon nanotubes

Mesh：

Substances：

Year:  2017        PMID： 28629088     DOI： 10.1016/j.msec.2017.05.089

Source DB:  PubMed          Journal:  Mater Sci Eng C Mater Biol Appl        ISSN： 0928-4931            Impact factor:   7.328


  6 in total

Review 1.  Carbon nanotubes-based drug delivery to cancer and brain.

Authors:  Qing Guo; Xian-Tao Shen; Yuan-Yuan Li; Shun-Qing Xu
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2017-10-20

2.  Description of Release Process of Doxorubicin from Modified Carbon Nanotubes.

Authors:  Dorota Chudoba; Monika Jażdżewska; Katarzyna Łudzik; Sebastian Wołoszczuk; Ewa Juszyńska-Gałązka; Mikołaj Kościński
Journal:  Int J Mol Sci       Date:  2021-11-05       Impact factor: 5.923

Review 3.  Comparison between Janus-Base Nanotubes and Carbon Nanotubes: A Review on Synthesis, Physicochemical Properties, and Applications.

Authors:  Sydney Griger; Ian Sands; Yupeng Chen
Journal:  Int J Mol Sci       Date:  2022-02-27       Impact factor: 5.923

Review 4.  Nanoparticle theranostics in cardiovascular inflammation.

Authors:  Neil MacRitchie; Valentina Di Francesco; Miguel Filipe Moreira Marques Ferreira; Tomasz J Guzik; Paolo Decuzzi; Pasquale Maffia
Journal:  Semin Immunol       Date:  2021-11-30       Impact factor: 11.130

Review 5.  Recent advancements in enzyme-incorporated nanomaterials: Synthesis, mechanistic formation, and applications.

Authors:  Shamini Anboo; Sie Yon Lau; Jibrail Kansedo; Pow-Seng Yap; Tony Hadibarata; Jaison Jeevanandam; Azlina H Kamaruddin
Journal:  Biotechnol Bioeng       Date:  2022-07-29       Impact factor: 4.395

6.  Design And Characterisation Of Novel Sorafenib-Loaded Carbon Nanotubes With Distinct Tumour-Suppressive Activity In Hepatocellular Carcinoma.

Authors:  Mahmoud Ma Elsayed; Mahmoud E Mostafa; Eman Alaaeldin; Hatem Aa Sarhan; Montaser ShA Shaykoon; Shady Allam; Ahmed Rh Ahmed; Bakheet Em Elsadek
Journal:  Int J Nanomedicine       Date:  2019-10-29
  6 in total

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