Cristiane M Silva1, Silvia A da Silva2, Margarida M de C Antunes3, Gisélia Alves Pontes da Silva4, Emanuel Sávio Cavalcanti Sarinho5, Katia G Brandt3. 1. Universidade Federal de Pernambuco (UFPE), Programa de Pós Graduação em Saúde da Criança e do Adolescente, Recife, PE, Brazil. Electronic address: cris.marrocos@yahoo.com.br. 2. Universidade Federal de Pernambuco (UFPE), Programa de Pós Graduação em Saúde da Criança e do Adolescente, Recife, PE, Brazil. 3. Universidade Federal de Pernambuco (UFPE), Departamento Materno-Infantil, Serviço de Gastroenterologia Pediátrica HC-UFPE, Recife, PE, Brazil. 4. Universidade Federal de Pernambuco (UFPE), Departamento Materno-Infantil, Programa de Pós Graduação em Saúde da Criança e do Adolescente, Recife, PE, Brazil. 5. Universidade Federal de Pernambuco (UFPE), Departamento Materno-Infantil, Programa de Pós Graduação em Saúde da Criança e do Adolescente, Recife, PE, Brazil; Universidade Federal de Pernambuco (UFPE), Departamento Materno-Infantil, Serviço de Alergologia e Imunologia HC-UFPE, Recife, PE, Brazil.
Abstract
OBJECTIVE: To verify whether infants with cow's milk protein allergy have inadequate vitamin D levels. METHODS: This cross-sectional study included 120 children aged 2 years or younger, one group with cow's milk protein allergy and a control group. The children were recruited at the pediatric gastroenterology, allergology, and pediatric outpatient clinics of a university hospital in the Northeast of Brazil. A questionnaire was administered to the caregiver and blood samples were collected for vitamin D quantification. Vitamin D levels <30ng/mL were considered inadequate. Vitamin D level was expressed as mean and standard deviation, and the frequency of the degrees of sufficiency and other variables, as proportions. RESULTS: Infants with cow's milk protein allergy had lower mean vitamin D levels (30.93 vs.35.29ng/mL; p=0.041) and higher deficiency frequency (20.3% vs.8.2; p=0.049) than the healthy controls. Exclusively or predominantly breastfed infants with cow's milk protein allergy had higher frequency of inadequate vitamin D levels (p=0.002). Regardless of sun exposure time, the groups had similar frequencies of inadequate vitamin D levels (p=0.972). CONCLUSIONS: Lower vitamin D levels were found in infants with CMPA, especially those who were exclusively or predominantly breastfed, making these infants a possible risk group for vitamin D deficiency.
OBJECTIVE: To verify whether infants with cow's milk protein allergy have inadequate vitamin D levels. METHODS: This cross-sectional study included 120 children aged 2 years or younger, one group with cow's milk protein allergy and a control group. The children were recruited at the pediatric gastroenterology, allergology, and pediatric outpatient clinics of a university hospital in the Northeast of Brazil. A questionnaire was administered to the caregiver and blood samples were collected for vitamin D quantification. Vitamin D levels <30ng/mL were considered inadequate. Vitamin D level was expressed as mean and standard deviation, and the frequency of the degrees of sufficiency and other variables, as proportions. RESULTS:Infants with cow's milk protein allergy had lower mean vitamin D levels (30.93 vs.35.29ng/mL; p=0.041) and higher deficiency frequency (20.3% vs.8.2; p=0.049) than the healthy controls. Exclusively or predominantly breastfed infants with cow's milk protein allergy had higher frequency of inadequate vitamin D levels (p=0.002). Regardless of sun exposure time, the groups had similar frequencies of inadequate vitamin D levels (p=0.972). CONCLUSIONS: Lower vitamin D levels were found in infants with CMPA, especially those who were exclusively or predominantly breastfed, making these infants a possible risk group for vitamin D deficiency.
Authors: Emilia Vassilopoulou; Gavriela Feketea; George N Konstantinou; Dimitris Zekakos Xypolias; Mina Valianatou; Maria Petrodimopoulou; Vasiliki Vourga; Ioannis Tasios; Nikolaos G Papadopoulos Journal: Front Nutr Date: 2022-03-30