Si Wen1, Fang He2, Xuejing Zhu3, Shuguang Yuan1, Hong Liu1, Lin Sun1. 1. Department of Nephrology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China. 2. Department of Nephrology, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-Sen University, Jiangmen, Guangdong, China. 3. Department of Nephrology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China. zhuxuejing5225209@163.com.
Abstract
OBJECTIVES: IFN-γ, CXCL16 and uPAR have recently been regarded as potential biomarkers in systemic lupus erythematosus (SLE). However, few researches have focused on the comparison of these three markers in SLE. We conducted this study to evaluate their role as biomarkers of disease activity and renal damage. METHODS: We enrolled 50 SLE patients with or without lupus nephritis (LN) and 15 healthy control subjects. The levels of IFN-γ, CXCL16, uPAR in serum, urine and renal tissues were detected by ELISA or immunohistochemistry. Relevant clinical and laboratory features were recorded. RESULTS: Serum and urine IFN-γ, CXCL16 and suPAR levels in SLE patients were significantly higher than that in healthy controls. Moreover, LN patients had higher levels than non-LN patients. A positive correlation was observed between these markers, and disease activity and suPAR had a stronger association with disease activity. The expression of these biomarkers in renal tissues was significantly higher in LN patients and was also associated with the activity of pathological lesions. CONCLUSIONS: IFN-γ, CXCL16 and uPAR are promising as effective biomarkers of disease activity, renal damage, and the activity of pathological lesions in SLE.
OBJECTIVES: IFN-γ, CXCL16 and uPAR have recently been regarded as potential biomarkers in systemic lupus erythematosus (SLE). However, few researches have focused on the comparison of these three markers in SLE. We conducted this study to evaluate their role as biomarkers of disease activity and renal damage. METHODS: We enrolled 50 SLEpatients with or without lupus nephritis (LN) and 15 healthy control subjects. The levels of IFN-γ, CXCL16, uPAR in serum, urine and renal tissues were detected by ELISA or immunohistochemistry. Relevant clinical and laboratory features were recorded. RESULTS: Serum and urine IFN-γ, CXCL16 and suPAR levels in SLEpatients were significantly higher than that in healthy controls. Moreover, LN patients had higher levels than non-LN patients. A positive correlation was observed between these markers, and disease activity and suPAR had a stronger association with disease activity. The expression of these biomarkers in renal tissues was significantly higher in LN patients and was also associated with the activity of pathological lesions. CONCLUSIONS: IFN-γ, CXCL16 and uPAR are promising as effective biomarkers of disease activity, renal damage, and the activity of pathological lesions in SLE.
Authors: Juliana Imgenberg-Kreuz; Jonas Carlsson Almlöf; Dag Leonard; Andrei Alexsson; Gunnel Nordmark; Maija-Leena Eloranta; Solbritt Rantapää-Dahlqvist; Anders A Bengtsson; Andreas Jönsen; Leonid Padyukov; Iva Gunnarsson; Elisabet Svenungsson; Christopher Sjöwall; Lars Rönnblom; Ann-Christine Syvänen; Johanna K Sandling Journal: Ann Rheum Dis Date: 2018-02-01 Impact factor: 19.103
Authors: Hadijat M Makinde; Deborah R Winter; Daniele Procissi; Elise V Mike; Ariel D Stock; Mary J Kando; Gaurav T Gadhvi; Steven Droho; Christina L Bloomfield; Salina T Dominguez; Maximilian G Mayr; Jeremy A Lavine; Chaim Putterman; Carla M Cuda Journal: Front Immunol Date: 2020-02-26 Impact factor: 7.561