Literature DB >> 28628382

UnPAKing RUNX3 functions-Both sides of the coin.

Arun Kumar1, Sandhya Sundaram2, Suresh K Rayala1, Ganesh Venkatraman3.   

Abstract

Post translational modifications of RUNX3 have been shown to play an important role in directing RUNX3 functions. In this review we highlight the phosphorylation dependent functions of RUNX3 as regulated by PAK1 and its implications on tumorigenesis.

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Year:  2017        PMID： 28628382      PMCID： PMC6548293          DOI： 10.1080/21541248.2017.1322667

Source DB:  PubMed          Journal:  Small GTPases        ISSN： 2154-1248


  38 in total

Review 1.  Rho GTPases in neuronal morphogenesis.

Authors:  L Luo
Journal:  Nat Rev Neurosci       Date:  2000-12       Impact factor: 34.870

2.  Cooperation between mDia1 and ROCK in Rho-induced actin reorganization.

Authors:  N Watanabe; T Kato; A Fujita; T Ishizaki; S Narumiya
Journal:  Nat Cell Biol       Date:  1999-07       Impact factor: 28.824

3.  Rho-Signaling-Directed YAP/TAZ Activity Underlies the Long-Term Survival and Expansion of Human Embryonic Stem Cells.

Authors:  Masatoshi Ohgushi; Maki Minaguchi; Yoshiki Sasai
Journal:  Cell Stem Cell       Date:  2015-08-27       Impact factor: 24.633

4.  Tech: a RhoA GEF selectively expressed in hippocampal and cortical neurons.

Authors:  Ruth Marx; Jennifer Henderson; James Wang; Jay M Baraban
Journal:  J Neurochem       Date:  2005-02       Impact factor: 5.372

5.  A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype.

Authors:  Miaoliang Liu; Arie Horowitz
Journal:  Mol Biol Cell       Date:  2006-02-08       Impact factor: 4.138

6.  The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization.

Authors:  Jeremy W Peck; Michael Oberst; Kerrie B Bouker; Emma Bowden; Peter D Burbelo
Journal:  J Biol Chem       Date:  2002-09-06       Impact factor: 5.157

Review 7.  Retinoic acid in development: towards an integrated view.

Authors:  Karen Niederreither; Pascal Dollé
Journal:  Nat Rev Genet       Date:  2008-06-10       Impact factor: 53.242

Review 8.  Rho-associated coiled-coil containing kinases (ROCK): structure, regulation, and functions.

Authors:  Linda Julian; Michael F Olson
Journal:  Small GTPases       Date:  2014-07-10

9.  Syx, a RhoA guanine exchange factor, is essential for angiogenesis in Vivo.

Authors:  Maija K Garnaas; Karen L Moodie; Miao-liang Liu; Ganesh V Samant; Keguo Li; Ruth Marx; Jay M Baraban; Arie Horowitz; Ramani Ramchandran
Journal:  Circ Res       Date:  2008-08-28       Impact factor: 17.367

10.  VEGF and Angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx.

Authors:  Siu P Ngok; Rory Geyer; Miaoliang Liu; Antonis Kourtidis; Sudesh Agrawal; Chuanshen Wu; Himabindu Reddy Seerapu; Laura J Lewis-Tuffin; Karen L Moodie; Deborah Huveldt; Ruth Marx; Jay M Baraban; Peter Storz; Arie Horowitz; Panos Z Anastasiadis
Journal:  J Cell Biol       Date:  2012-12-17       Impact factor: 10.539
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  1 in total

1.  Small peptide inhibitor from the sequence of RUNX3 disrupts PAK1-RUNX3 interaction and abrogates its phosphorylation-dependent oncogenic function.

Authors:  Rahul Kanumuri; Aruna Kumar Chelluboyina; Jayashree Biswal; Ravichandran Vignesh; Jaishree Pandian; Akkanapally Venu; B Vaishnavi; D J Leena; Jeyakanthan Jeyaraman; Kumaresan Ganesan; Gopala Krishna Aradhyam; Ganesh Venkatraman; Suresh K Rayala
Journal:  Oncogene       Date:  2021-07-12       Impact factor: 9.867
  1 in total

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