Literature DB >> 28628262

Catalytic Enantioselective Reaction of Allenylnitriles with Imines Using Chiral Bis(imidazoline)s Palladium(II) Pincer Complexes.

Masaru Kondo1,2, Masashi Omori1, Tsubasa Hatanaka3, Yasuhiro Funahashi3, Shuichi Nakamura1,2.   

Abstract

The first highly enantioselective reaction of allenylnitriles with imines has been developed. Excellent yields and enantioselectivities were observed for the reaction with various imines using chiral Phebim-PdII complexes. This process offers a simple and efficient synthetic route for various functionalized α-vinylidene-β-aminonitriles and their derivatives.
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  Lewis acids; allenyl compounds; asymmetric synthesis; pincer complex

Year:  2017        PMID： 28628262     DOI： 10.1002/anie.201702429

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  5 in total

1.  Catalytic Asymmetric Mannich Reaction of α-Fluoronitriles with Ketimines: Enantioselective and Diastereodivergent Construction of Vicinal Tetrasubstituted Stereocenters.

Authors:  Ransheng Ding; Zeus A De Los Santos; Christian Wolf
Journal:  ACS Catal       Date:  2019-02-06       Impact factor: 13.084

2.  Contrasteric coupling of allenes and tetrahydroisoquinolines by iron-catalysed allenic C(sp2)-H functionalisation.

Authors:  Yue Xia; Nicholas W Wade; Philip N Palermo; Yidong Wang; Yi-Ming Wang
Journal:  Chem Commun (Camb)       Date:  2021-12-09       Impact factor: 6.222

3.  Iron-Catalyzed Contrasteric Functionalization of Allenic C(sp2)-H Bonds: Synthesis of α-Aminoalkyl 1,1-Disubstituted Allenes.

Authors:  Yidong Wang; Sarah G Scrivener; Xiao-Dong Zuo; Ruihan Wang; Philip N Palermo; Ethan Murphy; Austin C Durham; Yi-Ming Wang
Journal:  J Am Chem Soc       Date:  2021-09-07       Impact factor: 16.383

4.  Photo and copper dual catalysis for allene syntheses from propargylic derivatives via one-electron process.

Authors:  Qi Liu; Jian Zheng; Xue Zhang; Shengming Ma
Journal:  Nat Commun       Date:  2022-06-08       Impact factor: 17.694

Review 5.  Synthesis and application in asymmetric catalysis of P-stereogenic pincer-metal complexes.

Authors:  Yijun Xiang; Qianyi Ge; Shulei Wu; Xing Zheng; Zehua Yang
Journal:  RSC Adv       Date:  2020-03-05       Impact factor: 4.036
  5 in total

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