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Literature DB >> 28628085

OPA1 and cardiolipin team up for mitochondrial fusion.

Abstract

Fusion between the inner membranes of two mitochondria requires the GTPase optic atrophy 1 (OPA1), but the molecular mechanism is poorly understood. A study now shows that fusion of two liposomes can be performed by OPA1 tethered to just one liposome, through an interaction with the phospholipid cardiolipin on the opposing liposome.

Entities: Chemical Disease Gene Species

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Year: 2017 PMID： 28628085 PMCID： PMC5757513 DOI： 10.1038/ncb3565

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

14 in total

1. Structural basis of mitochondrial tethering by mitofusin complexes.

Authors: Takumi Koshiba; Scott A Detmer; Jens T Kaiser; Hsiuchen Chen; J Michael McCaffery; David C Chan
Journal: Science Date: 2004-08-06 Impact factor: 47.728

2. OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation.

Authors: Tadato Ban; Jürgen A W Heymann; Zhiyin Song; Jenny E Hinshaw; David C Chan
Journal: Hum Mol Genet Date: 2010-02-25 Impact factor: 6.150

Review 3. Fusion and fission: interlinked processes critical for mitochondrial health.

Authors: David C Chan
Journal: Annu Rev Genet Date: 2012-08-29 Impact factor: 16.830

4. Distinct roles of the two isoforms of the dynamin-like GTPase Mgm1 in mitochondrial fusion.

Authors: Michael Zick; Stéphane Duvezin-Caubet; Anja Schäfer; Frank Vogel; Walter Neupert; Andreas S Reichert
Journal: FEBS Lett Date: 2009-06-06 Impact factor: 4.124

5. The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission.

Authors: Ruchika Anand; Timothy Wai; Michael J Baker; Nikolay Kladt; Astrid C Schauss; Elena Rugarli; Thomas Langer
Journal: J Cell Biol Date: 2014-03-10 Impact factor: 10.539

6. Structures of human mitofusin 1 provide insight into mitochondrial tethering.

Authors: Yuanbo Qi; Liming Yan; Caiting Yu; Xiangyang Guo; Xin Zhou; Xiaoyu Hu; Xiaofang Huang; Zihe Rao; Zhiyong Lou; Junjie Hu
Journal: J Cell Biol Date: 2016-12-05 Impact factor: 10.539

7. MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion.

Authors: Yu-Lu Cao; Shuxia Meng; Yang Chen; Jian-Xiong Feng; Dong-Dong Gu; Bing Yu; Yu-Jie Li; Jin-Yu Yang; Shuang Liao; David C Chan; Song Gao
Journal: Nature Date: 2017-01-23 Impact factor: 49.962

8. Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusion.

Authors: Rachel M DeVay; Lenin Dominguez-Ramirez; Laura L Lackner; Suzanne Hoppins; Henning Stahlberg; Jodi Nunnari
Journal: J Cell Biol Date: 2009-09-14 Impact factor: 10.539

9. Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation.

Authors: Prashant Mishra; Valerio Carelli; Giovanni Manfredi; David C Chan
Journal: Cell Metab Date: 2014-04-01 Impact factor: 27.287

10. OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L.

Authors: Zhiyin Song; Hsiuchen Chen; Maja Fiket; Christiane Alexander; David C Chan
Journal: J Cell Biol Date: 2007-08-20 Impact factor: 10.539

11 in total

1. Prohibitin is a positive modulator of mitochondrial function in PC12 cells under oxidative stress.

Authors: Corey J Anderson; Anja Kahl; Liping Qian; Anna Stepanova; Anatoly Starkov; Giovanni Manfredi; Costantino Iadecola; Ping Zhou
Journal: J Neurochem Date: 2018-08 Impact factor: 5.372

2. Pathogenicity evaluation and the genotype-phenotype analysis of OPA1 variants.

Authors: Xingyu Xu; Panfeng Wang; Xiaoyun Jia; Wenmin Sun; Shiqiang Li; Xueshan Xiao; J Fielding Hejtmancik; Qingjiong Zhang
Journal: Mol Genet Genomics Date: 2021-04-21 Impact factor: 3.291

Review 3. Mitochondrial regulation during male germ cell development.

Authors: Xiaoli Wang; Lisha Yin; Yujiao Wen; Shuiqiao Yuan
Journal: Cell Mol Life Sci Date: 2022-01-24 Impact factor: 9.261

Review 4. Mitochondrial damage & lipid signaling in traumatic brain injury.

Authors: Andrew M Lamade; Tamil S Anthonymuthu; Zachary E Hier; Yuan Gao; Valerian E Kagan; Hülya Bayır
Journal: Exp Neurol Date: 2020-04-11 Impact factor: 5.330

5. Urea Memory: Transient Cell Exposure to Urea Causes Persistent Mitochondrial ROS Production and Endothelial Dysfunction.

Authors: Maria d'Apolito; Anna Laura Colia; Enrica Manca; Massimo Pettoello-Mantovani; Michele Sacco; Angela Bruna Maffione; Michael Brownlee; Ida Giardino
Journal: Toxins (Basel) Date: 2018-10-11 Impact factor: 4.546

6. SS-31 Peptide Reverses the Mitochondrial Fragmentation Present in Fibroblasts From Patients With DCMA, a Mitochondrial Cardiomyopathy.

Authors: Pranav Machiraju; Xuemei Wang; Rasha Sabouny; Joshua Huang; Tian Zhao; Fatima Iqbal; Melissa King; Dimple Prasher; Arijit Lodha; Nerea Jimenez-Tellez; Amir Ravandi; Bob Argiropoulos; David Sinasac; Aneal Khan; Timothy E Shutt; Steven C Greenway
Journal: Front Cardiovasc Med Date: 2019-11-15