Literature DB >> 28627528

Novel chemical probes for the investigation of nonribosomal peptide assembly.

Y T Candace Ho1, Daniel J Leng1, Francesca Ghiringhelli2, Ina Wilkening1, Dexter P Bushell1, Otto Kostner3, Elena Riva1, Judith Havemann1, Daniele Passarella4, Manuela Tosin1.   

Abstract

Chemical probes were devised and evaluated for the capture of biosynthetic intermediates involved in the bio-assembly of the nonribosomal peptide echinomycin. Putative intermediate peptide species were isolated and characterised, providing fresh insights into pathway substrate flexibility and paving the way for novel chemoenzymatic approaches towards unnatural peptides.

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Year:  2017        PMID： 28627528     DOI： 10.1039/c7cc02427d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  Triplex-Forming Peptide Nucleic Acids with Extended Backbones.

Authors:  Vipin Kumar; Nikita Brodyagin; Eriks Rozners
Journal:  Chembiochem       Date:  2020-08-31       Impact factor: 3.164

Review 2.  Trapping interactions between catalytic domains and carrier proteins of modular biosynthetic enzymes with chemical probes.

Authors:  Andrew M Gulick; Courtney C Aldrich
Journal:  Nat Prod Rep       Date:  2018-11-14       Impact factor: 13.423

3.  Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity.

Authors:  Thierry Izoré; Y T Candace Ho; Joe A Kaczmarski; Athina Gavriilidou; Ka Ho Chow; David L Steer; Robert J A Goode; Ralf B Schittenhelm; Julien Tailhades; Manuela Tosin; Gregory L Challis; Elizabeth H Krenske; Nadine Ziemert; Colin J Jackson; Max J Cryle
Journal:  Nat Commun       Date:  2021-05-04       Impact factor: 14.919
  3 in total

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