| Literature DB >> 28626833 |
Bryan G Yipp1,2, Jung Hwan Kim1,2, Ronald Lima2,3, Lori D Zbytnuik2,3, Björn Petri2,4,5, Nick Swanlund2,3, May Ho2,5, Vivian G Szeto2,3, Tamar Tak6, Leo Koenderman6, Peter Pickkers7, Anton T J Tool8, Taco W Kuijpers8, Timo K van den Berg8,9, Mark R Looney10, Matthew F Krummel11, Paul Kubes1,2,3,4,5.
Abstract
Bloodstream infection is a hallmark of sepsis, a medically emergent condition requiring rapid treatment. However, upregulation of host defense proteins through toll-like receptors and NFκB requires hours after endotoxin detection. Using confocal pulmonary intravital microscopy, we identified that the lung provides a TLR4-Myd88-and abl tyrosine kinase-dependent niche for immediate CD11b-dependent neutrophil responses to endotoxin and Gram-negative bloodstream pathogens. In an in vivo model of bacteremia, neutrophils crawled to and rapidly phagocytosed Escherichia coli sequestered to the lung endothelium. Therefore, the lung capillaries provide a vascular defensive niche whereby endothelium and neutrophils cooperate for immediate detection and capture of disseminating pathogens.Entities:
Year: 2017 PMID： 28626833 PMCID： PMC5472445 DOI： 10.1126/sciimmunol.aam8929
Source DB: PubMed Journal: Sci Immunol ISSN： 2470-9468