Hamid Vaez1, Amin Salehi-Abargouei2, Farzad Khademi3. 1. PhD, Department of Microbiology, School of Medicine, Zabol University of Medical Sciences, Shahid Rajaei Street, P.O. code 9861663335, Zabol, Iran. 2. PhD, Department of Nutrition, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Bahonar Square, PO code 8915173160, Yazd, Iran. 3. PhD, Department of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Daneshgah Street, PO code 5618985991, Ardabil, Iran.
Abstract
INTRODUCTION: Imipenem-resistant Pseudomonas aeruginosa (IRPA), due to resistance to different classes of antibiotics and its remarkable capacity to survive in harsh and adverse conditions such as those in the hospital environment, is considered a serious threat to the healthcare system. Given the great impact of IRPA on patients' outcome and in order to possibly improve antibiotic prescription, this study was conducted to determine the prevalence of clinical isolates of IRPA in different parts of Iran. METHODS: A systematic literature search was performed in PubMed, Web of Science, Google Scholar and Scopus, as well as in two Iranian domestic search engines, i.e., Iranian Scientific Information Database and Magiran. Finally, after applying exclusion and inclusion criteria 37 articles with full-texts describing the prevalence of imipenem-resistant P. aeruginosa were selected for meta-analysis and systematic review. RESULTS: The pooled estimation of 5227 P. aeruginosa isolates in this analysis showed that the percentage of imipenem-resistant P. aeruginosa is about 54% in the Iranian population (95%CI: 0.47-0.62, logit event rate=0.19, 95%CI: -0.12,0.49). CONCLUSION: The findings of this analysis show that in the majority of Iranian hospitals the relative frequency of IRPA is high, therefore, in order to prevent further dissemination of IRPA, more appropriate antibiotic prescription and infection control policies must be implemented by decision-makers.
INTRODUCTION:Imipenem-resistant Pseudomonas aeruginosa (IRPA), due to resistance to different classes of antibiotics and its remarkable capacity to survive in harsh and adverse conditions such as those in the hospital environment, is considered a serious threat to the healthcare system. Given the great impact of IRPA on patients' outcome and in order to possibly improve antibiotic prescription, this study was conducted to determine the prevalence of clinical isolates of IRPA in different parts of Iran. METHODS: A systematic literature search was performed in PubMed, Web of Science, Google Scholar and Scopus, as well as in two Iranian domestic search engines, i.e., Iranian Scientific Information Database and Magiran. Finally, after applying exclusion and inclusion criteria 37 articles with full-texts describing the prevalence of imipenem-resistant P. aeruginosa were selected for meta-analysis and systematic review. RESULTS: The pooled estimation of 5227 P. aeruginosa isolates in this analysis showed that the percentage of imipenem-resistant P. aeruginosa is about 54% in the Iranian population (95%CI: 0.47-0.62, logit event rate=0.19, 95%CI: -0.12,0.49). CONCLUSION: The findings of this analysis show that in the majority of Iranian hospitals the relative frequency of IRPA is high, therefore, in order to prevent further dissemination of IRPA, more appropriate antibiotic prescription and infection control policies must be implemented by decision-makers.
Authors: M Hakemi Vala; M Hallajzadeh; A Hashemi; H Goudarzi; M Tarhani; M Sattarzadeh Tabrizi; F Bazmi Journal: Ann Burns Fire Disasters Date: 2014-03-31
Authors: M Massongo; L Ngando; E W Pefura Yone; Ariane NZouankeu; W Mbanzouen; M C Fonkoua; A Ngandjio; J Tchatchueng; D Barger; M C Tejiokem Journal: Biomed Res Int Date: 2021-05-22 Impact factor: 3.411