Jeong-Ho Hong1, Sung-Il Sohn1, Jaehyuk Kwak1, Joonsang Yoo1, Hyuk Won Chang1, O-Ki Kwon1, Cheolkyu Jung1, Inyoung Chung1, Hee-Joon Bae1, Ji Sung Lee1, Moon-Ku Han2. 1. From the Department of Neurology (J.-H.H., S.-I.S., J.K., J.Y.); Department of Radiology (H.W.C.), Keimyung University School of Medicine, Dongsan Medical Center, Daegu, Korea; Department of Neurology (I.C., H.-J.B., M.-K.H.), Department of Neurosurgery (O.-K.K.), and Department of Radiology (C.J.), Seoul National University Bundang Hospital, Seongnam, Korea; and Clinical Trial Center, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea (J.S.L.). 2. From the Department of Neurology (J.-H.H., S.-I.S., J.K., J.Y.); Department of Radiology (H.W.C.), Keimyung University School of Medicine, Dongsan Medical Center, Daegu, Korea; Department of Neurology (I.C., H.-J.B., M.-K.H.), Department of Neurosurgery (O.-K.K.), and Department of Radiology (C.J.), Seoul National University Bundang Hospital, Seongnam, Korea; and Clinical Trial Center, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea (J.S.L.). mkhan@snu.ac.kr.
Abstract
BACKGROUND AND PURPOSE: We investigated whether statin pretreatment can dose dependently reduce periprocedural complications in patients undergoing carotid artery stenting because of symptomatic carotid artery stenosis. METHODS: We enrolled a consecutive series of 397 symptomatic carotid artery stenosis (≥50% stenosis on conventional angiography) treated with carotid artery stenting at 2 tertiary university hospitals over a decade. Definition of periprocedural complications included any stroke, myocardial infarction, and death within 1 month after or during the procedure. Statin pretreatment was divided into 3 categories according to the atorvastatin equivalent dose: none (n=158; 39.8%), standard dose (<40 mg of atorvastatin, n=155; 39.0%), and high dose (≥40 mg; n=84; 21.2%). A multivariable logistic regression analysis with the generalized estimating equation method was used to investigate independent factors in periprocedural complications. RESULTS: The patients' mean age was 68.7 years (81.6% men). The periprocedural complication rates across the 3 categories of statin use were 12.0%, 4.5%, and 1.2%. After adjustment, a change in the atorvastatin dose category was associated with reduction in the odds of periprocedural complications for each change in dose category (standard-dose statin: odds ratio, 0.24; 95% confidence interval, 0.07-0.81; high-dose statin: odds ratio, 0.11; 95% confidence interval, 0.01-0.96; P for trend=0.01). Administration of antiplatelet drugs was also an independent factor in periprocedural complications (OR, 0.18; 95% CI, 0.05-0.69). CONCLUSIONS: This study shows that statin pretreatment may reduce the incidence of periprocedural complications dose dependently in patients with symptomatic carotid artery stenting.
BACKGROUND AND PURPOSE: We investigated whether statin pretreatment can dose dependently reduce periprocedural complications in patients undergoing carotid artery stenting because of symptomatic carotid artery stenosis. METHODS: We enrolled a consecutive series of 397 symptomatic carotid artery stenosis (≥50% stenosis on conventional angiography) treated with carotid artery stenting at 2 tertiary university hospitals over a decade. Definition of periprocedural complications included any stroke, myocardial infarction, and death within 1 month after or during the procedure. Statin pretreatment was divided into 3 categories according to the atorvastatin equivalent dose: none (n=158; 39.8%), standard dose (<40 mg of atorvastatin, n=155; 39.0%), and high dose (≥40 mg; n=84; 21.2%). A multivariable logistic regression analysis with the generalized estimating equation method was used to investigate independent factors in periprocedural complications. RESULTS: The patients' mean age was 68.7 years (81.6% men). The periprocedural complication rates across the 3 categories of statin use were 12.0%, 4.5%, and 1.2%. After adjustment, a change in the atorvastatin dose category was associated with reduction in the odds of periprocedural complications for each change in dose category (standard-dose statin: odds ratio, 0.24; 95% confidence interval, 0.07-0.81; high-dose statin: odds ratio, 0.11; 95% confidence interval, 0.01-0.96; P for trend=0.01). Administration of antiplatelet drugs was also an independent factor in periprocedural complications (OR, 0.18; 95% CI, 0.05-0.69). CONCLUSIONS: This study shows that statin pretreatment may reduce the incidence of periprocedural complications dose dependently in patients with symptomatic carotid artery stenting.
Authors: Patric Liang; Yoel Solomon; Nicholas J Swerdlow; Chun Li; Rens R B Varkevisser; Livia E V M de Guerre; Marc L Schermerhorn Journal: J Vasc Surg Date: 2020-02-13 Impact factor: 4.268
Authors: Mohamad A Hussain; Gustavo Saposnik; Sneha Raju; Konrad Salata; Muhammad Mamdani; Jack V Tu; Deepak L Bhatt; Subodh Verma; Mohammed Al-Omran Journal: J Am Heart Assoc Date: 2018-08-21 Impact factor: 5.501