| Literature DB >> 28625830 |
Steinunn Baekkeskov1, Jeffrey A Hubbell2, Edward A Phelps3.
Abstract
Type 1 diabetes is an autoimmune disease marked by the destruction of insulin-producing beta cells in the pancreatic islets. Strategies to delay onset or prevent the autoimmune recognition of beta cell antigens or T cell-mediated killing of beta cells have mainly focused on systemic immunomodulation and antigen-specific immunotherapy. To bridge the fields of type 1 diabetes immunology and biomaterials engineering, this article will review recent trends in the etiology of type 1 diabetes immunopathology and will focus on the contributions of emerging bioengineered strategies in the fight against beta cell autoimmunity in type 1 diabetes.Entities:
Keywords: Autoimmunity; Biomaterials; Tolerance; Type 1 diabetes
Mesh:
Year: 2017 PMID: 28625830 DOI: 10.1016/j.addr.2017.06.007
Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN: 0169-409X Impact factor: 15.470