Dudung Angkasa1,2,3, Victor Tambunan1, Helda Khusun2, Fiastuti Witjaksono1, Rina Agustina4. 1. Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia. 2. Southeast Asian Ministers of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON)/Pusat Kajian Gizi Regional (PKGR), Universitas Indonesia, Jakarta, Indonesia. 3. Department of Nutrition, Faculty of Health Sciences, Universitas Esa Unggul, Jakarta, Indonesia. 4. Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia. Email: dr.rinaagustina@gmail.com and r.agustina@ui.ac.id.
Abstract
BACKGROUND: Omega-3 fatty acid intake during pregnancy has been confirmed to affect newborn birth outcomes in the developed world. However, the association between maternal omega-3 fatty acid intake and birth size is unknown in developing countries. OBJECTIVE: To examine the association of maternal omega-3 fatty acid intake with newborn birth size. METHODS AND STUDY DESIGN: A cross-sectional study was conducted, involving 282 pregnant women aged 19-40 years who had a gestational age of >32 weeks and received antenatal care at 10 health centres and one referral hospital in East Jakarta, Indonesia. Maternal habitual intake of omega-3 fatty acids, including α-linolenic acid, docosahexaenoic acid, and eicosapentaenoic acid, was assessed using a semiquantitative food frequency questionnaire. Birth weight and head circumference were measured using a paediatric weighing scale and tape, respectively, and birth length was obtained from medical records. Multiple linear regression analysis was performed to provide adjusted associations. RESULTS: The median total intake of omega-3 fatty acids, docosahexaenoic acid, eicosapentaenoic acid, and α-linolenic acid was lower than the recommended dietary intake. The newborns of mothers with an α-linolenic acid intake lower than 0.82 g/d had a significantly lower (β=114, 95% confidence interval=-216, -13.5; p=0.014) weight compared with those of mothers with high α-linolenic acid intake, after adjustment for confounding factors. CONCLUSION: Inadequate maternal intake of α-linolenic acid, but not omega-3 fatty acids, docosahexaenoic acid, or eicosapentaenoic acid, was associated with lower birth weight. Enhanced promotion of consumption of foods rich in essential fatty acids during pregnancy may facilitate attaining optimal infant weight in urban areas.
BACKGROUND:Omega-3 fatty acid intake during pregnancy has been confirmed to affect newborn birth outcomes in the developed world. However, the association between maternal omega-3 fatty acid intake and birth size is unknown in developing countries. OBJECTIVE: To examine the association of maternal omega-3 fatty acid intake with newborn birth size. METHODS AND STUDY DESIGN: A cross-sectional study was conducted, involving 282 pregnant women aged 19-40 years who had a gestational age of >32 weeks and received antenatal care at 10 health centres and one referral hospital in East Jakarta, Indonesia. Maternal habitual intake of omega-3 fatty acids, including α-linolenic acid, docosahexaenoic acid, and eicosapentaenoic acid, was assessed using a semiquantitative food frequency questionnaire. Birth weight and head circumference were measured using a paediatric weighing scale and tape, respectively, and birth length was obtained from medical records. Multiple linear regression analysis was performed to provide adjusted associations. RESULTS: The median total intake of omega-3 fatty acids, docosahexaenoic acid, eicosapentaenoic acid, and α-linolenic acid was lower than the recommended dietary intake. The newborns of mothers with an α-linolenic acid intake lower than 0.82 g/d had a significantly lower (β=114, 95% confidence interval=-216, -13.5; p=0.014) weight compared with those of mothers with high α-linolenic acid intake, after adjustment for confounding factors. CONCLUSION: Inadequate maternal intake of α-linolenic acid, but not omega-3 fatty acids, docosahexaenoic acid, or eicosapentaenoic acid, was associated with lower birth weight. Enhanced promotion of consumption of foods rich in essential fatty acids during pregnancy may facilitate attaining optimal infant weight in urban areas.
Authors: Melinda Phang; Hasthi U Dissanayake; Rowena L McMullan; Jon Hyett; Adrienne Gordon; Manohar L Garg; Michael R Skilton Journal: Curr Dev Nutr Date: 2018-10-18