Kamran Ullah1, Tanzil Ur Rahman1, Dan-Dan Wu2, Xian-Hua Lin2, Ye Liu2, Xiao-Yan Guo3, Peter C K Leung4, Run-Ju Zhang5, He-Feng Huang6, Jian-Zhong Sheng7. 1. The Key Laboratory of Reproductive Genetics, Ministry of Education (Zhejiang University), Hangzhou, China; Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, China. 2. The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. 3. The Key Laboratory of Reproductive Genetics, Ministry of Education (Zhejiang University), Hangzhou, China; Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University, Hangzhou, China. 4. Department of Obstetrics and Gynecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada. 5. Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University, Hangzhou, China. 6. The Key Laboratory of Reproductive Genetics, Ministry of Education (Zhejiang University), Hangzhou, China; The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University, Hangzhou, China. 7. The Key Laboratory of Reproductive Genetics, Ministry of Education (Zhejiang University), Hangzhou, China; Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, China. Electronic address: shengjz@zju.edu.cn.
Abstract
BACKGROUND: Polycystic ovary syndrome (PCOS) is commonly characterized by obesity, insulin resistance (IR), hyperandrogenemia and hirsutism. Following the reported relationship between phoenixin-14 and gonadotropin production in rat hypothalamic-pituitary-gonadal axis, the present study was designed to investigate the circulating concentrations of phoenixin-14 and their associations with the concentrations of sex hormones including luteinizing hormone (LH), follicular stimulating hormone (FSH), estradiol (E2), progesterone (P4) and total testosterone (TT) in PCOS patients. METHODS: A total of 41 women with diagnosed PCOS using Rotterdam criteria and 37 healthy individuals were enrolled in the study. RESULTS: Serum phoenixin-14 concentration in PCOS patients (n=41) was 0.515±0.044ng/ml, significantly higher than that in healthy controls (0.289±0.046ng/ml, n=37). PCOS patients had higher serum LH, dehydroepiandrosterone and fasting blood glucose concentrations, and higher index of homeostasis model of assessment-IR than those in healthy women. Correlation analysis showed significantly positive correlations of phoenixin-14 with LH, FSH, TT, P4, BMI and nesfatin-1 concentrations, and significantly negative correlations with E2 and serum insulin (FSI) concentrations, respectively. CONCLUSIONS: Compared to control women, PCOS patients had significantly increased serum phoenixin-14, LH and androgen concentrations. The positive correlations of phoenixin-14 concentrations with LH and TT concentrations suggest a possible role of phoenixin-14 in the development of PCOS.
BACKGROUND:Polycystic ovary syndrome (PCOS) is commonly characterized by obesity, insulin resistance (IR), hyperandrogenemia and hirsutism. Following the reported relationship between phoenixin-14 and gonadotropin production in rathypothalamic-pituitary-gonadal axis, the present study was designed to investigate the circulating concentrations of phoenixin-14 and their associations with the concentrations of sex hormones including luteinizing hormone (LH), follicular stimulating hormone (FSH), estradiol (E2), progesterone (P4) and total testosterone (TT) in PCOSpatients. METHODS: A total of 41 women with diagnosed PCOS using Rotterdam criteria and 37 healthy individuals were enrolled in the study. RESULTS: Serum phoenixin-14 concentration in PCOSpatients (n=41) was 0.515±0.044ng/ml, significantly higher than that in healthy controls (0.289±0.046ng/ml, n=37). PCOSpatients had higher serum LH, dehydroepiandrosterone and fasting blood glucose concentrations, and higher index of homeostasis model of assessment-IR than those in healthy women. Correlation analysis showed significantly positive correlations of phoenixin-14 with LH, FSH, TT, P4, BMI and nesfatin-1 concentrations, and significantly negative correlations with E2 and serum insulin (FSI) concentrations, respectively. CONCLUSIONS: Compared to control women, PCOSpatients had significantly increased serum phoenixin-14, LH and androgen concentrations. The positive correlations of phoenixin-14 concentrations with LH and TT concentrations suggest a possible role of phoenixin-14 in the development of PCOS.
Authors: Timothy S Breton; Casey A Murray; Sierra R Huff; Anyssa M Phaneuf; Bethany M Tripp; Sarah J Patuel; Christopher J Martyniuk; Matthew A DiMaggio Journal: Sci Rep Date: 2022-06-08 Impact factor: 4.996
Authors: Lauren M Stein; Christopher J Haddock; Willis K Samson; Grant R Kolar; Gina L C Yosten Journal: Peptides Date: 2018-06-19 Impact factor: 3.750