Ignacio Obeso1, Leonora Wilkinson2, James T Teo3, Penelope Talelli3, John C Rothwell3, Marjan Jahanshahi4. 1. HM Hospitales - Centro Integral en Neurociencias HM CINAC, HM Hospitales Puerta del Sur, 28938, Móstoles & CEU-San Pablo University, Madrid, Spain. 2. Behavioral Neurology Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892-1430, United States. 3. Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, WC1N3BG, United Kingdom. 4. Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, WC1N3BG, United Kingdom. Electronic address: m.jahanshai@ucl.ac.uk.
Abstract
BACKGROUND: Stopping an ongoing motor response or resolving conflict induced by conflicting stimuli are associated with activation of a right-lateralized network of inferior frontal gyrus (IFG), pre-supplementary motor area (pre-SMA) and subthalamic nucleus (STN). However, the roles of the right IFG and pre-SMA in stopping a movement and in conflict resolution remain unclear. We used continuous theta burst stimulation (cTBS) to examine the involvement of the right IFG and pre-SMA in inhibition and conflict resolution using the conditional stop signal task. METHODS: We measured stop signal reaction time (SSRT, measure of reactive inhibition), response delay effect (RDE, measure of proactive action restraint) and conflict induced slowing (CIS, measure of conflict resolution). RESULTS: Stimulation over the pre-SMA resulted in significantly shorter SSRTs (improved inhibition) compared to sham cTBS. This effect was not observed for CIS, RDE, or any other measures. cTBS over the right IFG had no effect on SSRT, CIS, RDE or on any other measure. CONCLUSIONS: The improvement of SSRT with cTBS over the pre-SMA suggests its critical contribution to stopping ongoing movements.
BACKGROUND: Stopping an ongoing motor response or resolving conflict induced by conflicting stimuli are associated with activation of a right-lateralized network of inferior frontal gyrus (IFG), pre-supplementary motor area (pre-SMA) and subthalamic nucleus (STN). However, the roles of the right IFG and pre-SMA in stopping a movement and in conflict resolution remain unclear. We used continuous theta burst stimulation (cTBS) to examine the involvement of the right IFG and pre-SMA in inhibition and conflict resolution using the conditional stop signal task. METHODS: We measured stop signal reaction time (SSRT, measure of reactive inhibition), response delay effect (RDE, measure of proactive action restraint) and conflict induced slowing (CIS, measure of conflict resolution). RESULTS: Stimulation over the pre-SMA resulted in significantly shorter SSRTs (improved inhibition) compared to sham cTBS. This effect was not observed for CIS, RDE, or any other measures. cTBS over the right IFG had no effect on SSRT, CIS, RDE or on any other measure. CONCLUSIONS: The improvement of SSRT with cTBS over the pre-SMA suggests its critical contribution to stopping ongoing movements.
Authors: Charlotte Pscherer; Moritz Mückschel; Lena Summerer; Annet Bluschke; Christian Beste Journal: Hum Brain Mapp Date: 2019-06-20 Impact factor: 5.038
Authors: José A Pineda-Pardo; Ignacio Obeso; Pasqualina Guida; Michele Dileone; Bryan A Strange; José A Obeso; Antonio Oliviero; Guglielmo Foffani Journal: Commun Biol Date: 2019-10-31
Authors: Elizabeth A Disbrow; Nathaniel D Glassy; Elizabeth M Dressler; Kimberley Russo; Elizabeth A Franz; Robert S Turner; Maria I Ventura; Leighton Hinkley; Richard Zweig; Srikantan S Nagarajan; Christina R Ledbetter; Karen A Sigvardt Journal: PLoS One Date: 2022-03-04 Impact factor: 3.240