| Literature DB >> 28624105 |
Jasmijn Selten1, Andrea Schlegel2, Jeroen de Jonge3, Philipp Dutkowski4.
Abstract
The demand of donor livers for transplantation exceeds the supply. In an attempt to maximize the number of potentially usable donor livers, several centers are exploring the role of machine perfusion. This review provides an update on machine perfusion strategies and basic concepts, based on current clinical issues, and discuss challenges, including currently used biomarkers for assessing the quality and viability of perfused organs. The potential benefits of machine perfusion on immunogenicity and the consequences on post-operative immunosuppression management are discussed.Entities:
Keywords: HOPE; Hypothermic; Liver transplantation; Machine perfusion; Normothermic; Preservation
Mesh:
Year: 2017 PMID: 28624105 DOI: 10.1016/j.bpg.2017.04.001
Source DB: PubMed Journal: Best Pract Res Clin Gastroenterol ISSN: 1521-6918 Impact factor: 3.043