Literature DB >> 2862329

Excitatory aminoacid antagonists provide a therapeutic approach to neurological disorders.

R Schwarcz, B Meldrum.   

Abstract

Excessive excitation by neurotransmitters can cause the death of neurons. This excitotoxic action may be responsible for neuronal loss in stroke, cerebral palsy, epilepsy, ageing and Alzheimer's disease, Huntington's disease, and other chronic degenerative disorders. Compounds acting specifically to antagonise excitatory neurotransmission offer a novel therapeutic approach to these disorders.

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Year:  1985        PMID： 2862329     DOI： 10.1016/s0140-6736(85)90238-7

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  28 in total

1.  Pharmacological characterization of the N-methyl-D-aspartate (NMDA) receptor-channel in rodent and dog brain and rat spinal cord using [3H]MK-801 binding.

Authors:  N A Sharif; J L Nunes; R L Whiting
Journal:  Neurochem Res       Date:  1991-05       Impact factor: 3.996

Review 2.  Antidepressant Actions of Ketamine Mediated by the Mechanistic Target of Rapamycin, Nitric Oxide, and Rheb.

Authors:  Maged M Harraz; Solomon H Snyder
Journal:  Neurotherapeutics       Date:  2017-07       Impact factor: 7.620

3.  Interaction of the NMDA receptor noncompetitive antagonist MK-801 with model and native membranes.

Authors:  J Moring; L A Niego; L M Ganley; M W Trumbore; L G Herbette
Journal:  Biophys J       Date:  1994-12       Impact factor: 4.033

4.  Stimulation of 5-HT1A receptors in the dorsal hippocampus and inhibition of limbic seizures induced by kainic acid in rats.

Authors:  M Gariboldi; P Tutka; R Samanin; A Vezzani
Journal:  Br J Pharmacol       Date:  1996-11       Impact factor: 8.739

Review 5.  The kynurenine pathway and the brain: Challenges, controversies and promises.

Authors:  Robert Schwarcz; Trevor W Stone
Journal:  Neuropharmacology       Date:  2016-08-07       Impact factor: 5.250

6.  The effect of MK-801 and other antagonists of NMDA-type glutamate receptors on brain-stimulation reward.

Authors:  L J Herberg; I C Rose
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

7.  Dextrorphan attenuates the behavioral consequences of ischemia and the biochemical consequences of anoxia: possible role of N-methyl-d-aspartate receptor antagonism and ATP replenishing action in its cerebroprotecting profile.

Authors:  N Himori; Y Tanaka; M Kurasawa; K Mishima; N Akaike; M Imai; K Ueno; T Matsukura; H Watanabe
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

8.  Developmental expression of N-methyl-D-aspartate (NMDA)-induced neurotoxicity, NMDA receptor function, and the NMDAR1 and glutamate-binding protein subunits in cerebellar granule cells in primary cultures.

Authors:  Y Xia; R E Ragan; E E Seah; M L Michaelis; E K Michaelis
Journal:  Neurochem Res       Date:  1995-05       Impact factor: 3.996

9.  The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

Authors:  E H Wong; J A Kemp; T Priestley; A R Knight; G N Woodruff; L L Iversen
Journal:  Proc Natl Acad Sci U S A       Date:  1986-09       Impact factor: 11.205

10.  Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate.

Authors:  Xinkun Wang; Xiaodong Bao; Ranu Pal; Abdulbaki Agbas; Elias K Michaelis
Journal:  BMC Genomics       Date:  2010-06-07       Impact factor: 3.969
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