Literature DB >> 28623093

The role of SMARCAL1 in replication fork stability and telomere maintenance.

Natalia Lugli1, Sotirios K Sotiriou1, Thanos D Halazonetis2.   

Abstract

SMARCAL1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A-Like 1), also known as HARP, is an ATP-dependent annealing helicase that stabilizes replication forks during DNA damage. Mutations in this gene are the cause of Schimke immune-osseous dysplasia (SIOD), an autosomal recessive disorder characterized by T-cell immunodeficiency and growth dysfunctions. In this review, we summarize the main roles of SMARCAL1 in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress.
Copyright © 2017 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  DNA replication; DNA replication stress; SMARCAL1; Telomeres

Mesh：

Substances：

Year:  2017        PMID： 28623093     DOI： 10.1016/j.dnarep.2017.06.015

Source DB:  PubMed          Journal:  DNA Repair (Amst)        ISSN： 1568-7856


  5 in total

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