| Literature DB >> 28622981 |
Min Jiang1, Jiangfeng Ma2, Mingke Wu3, Rongming Liu4, Liya Liang4, Fengxue Xin3, Wenming Zhang5, Honghua Jia2, Weiliang Dong3.
Abstract
Succinic acid is a four-carbon dicarboxylic acid, which has attracted much interest due to its abroad usage as a precursor of many industrially important chemicals in the food, chemicals, and pharmaceutical industries. Facing the shortage of crude oil supply and demand of sustainable development, biological production of succinic acid from renewable resources has become a topic of worldwide interest. In recent decades, robust producing strain selection, metabolic engineering of model strains, and process optimization for succinic acid production have been developed. This review provides an overview of succinic acid producers and cultivation technology, highlight some of the successful metabolic engineering approaches.Entities:
Keywords: Carbon dioxide; Metabolic engineering; NADH/NAD(+); Renewable resources; Succinic acid
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Year: 2017 PMID： 28622981 DOI： 10.1016/j.biortech.2017.05.209
Source DB: PubMed Journal: Bioresour Technol ISSN： 0960-8524 Impact factor: 9.642