Literature DB >> 28622979

Whole-genome sequencing for identification of the source in hospital-acquired Legionnaires' disease.

A M Rosendahl Madsen1, A Holm2, T G Jensen2, E Knudsen2, H Lundgaard2, M N Skov2, S A Uldum3, M Kemp2.   

Abstract

Acquisition of Legionnaires' disease is a serious complication of hospitalization. Rapid determination of whether or not the infection is caused by strains of Legionella pneumophila in the hospital environment is crucial to avoid further cases. This study investigated the use of whole-genome sequencing to identify the source of infection in hospital-acquired Legionnaires' disease. Phylogenetic analyses showed close relatedness between one patient isolate and a strain found in hospital water, confirming suspicion of nosocomial infection. It was found that whole-genome sequencing can be a useful tool in the investigation of hospital-acquired Legionnaires' disease.
Copyright © 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Legionella; Nosocomial infection; Whole-genome sequencing

Mesh：

Year:  2017        PMID： 28622979     DOI： 10.1016/j.jhin.2017.04.020

Source DB:  PubMed          Journal:  J Hosp Infect        ISSN： 0195-6701            Impact factor:   3.926


  5 in total

Review 1.  Whole-Genome Sequencing of Bacterial Pathogens: the Future of Nosocomial Outbreak Analysis.

Authors:  Scott Quainoo; Jordy P M Coolen; Sacha A F T van Hijum; Martijn A Huynen; Willem J G Melchers; Willem van Schaik; Heiman F L Wertheim
Journal:  Clin Microbiol Rev       Date:  2017-10       Impact factor: 26.132

2.  Air-conditioner cooling towers as complex reservoirs and continuous source of Legionella pneumophila infection evidenced by a genomic analysis study in 2017, Switzerland.

Authors:  Daniel Wüthrich; Sylvia Gautsch; Ruth Spieler-Denz; Olivier Dubuis; Valeria Gaia; Jacob Moran-Gilad; Vladimira Hinic; Helena Mb Seth-Smith; Christian H Nickel; Sarah Tschudin-Sutter; Stefano Bassetti; Monika Haenggi; Peter Brodmann; Simon Fuchs; Adrian Egli
Journal:  Euro Surveill       Date:  2019-01

Review 3.  Status and potential of bacterial genomics for public health practice: a scoping review.

Authors:  Nina Van Goethem; Tine Descamps; Brecht Devleesschauwer; Nancy H C Roosens; Nele A M Boon; Herman Van Oyen; Annie Robert
Journal:  Implement Sci       Date:  2019-08-13       Impact factor: 7.327

4.  Non-Legionella pneumophila serogroup 1 pneumonia: Diagnosis of a nosocomial legionellosis with the Biofire Pneumonia plus panel.

Authors:  Camille Courboules; Nathalie Dournon; Christine Lawrence; Latifa Noussair; Ghislaine Descours; Valérie Sivadon-Tardy; Sophie Jarraud; Jean-Louis Herrmann; Jean-Louis Gaillard; Florence Espinasse; Faten El Sayed; Anne-Laure Roux
Journal:  IDCases       Date:  2022-03-25

5.  A Tale of Four Danish Cities: Legionella pneumophila Diversity in Domestic Hot Water and Spatial Variations in Disease Incidence.

Authors:  Søren A Uldum; Lars G Schjoldager; Sharmin Baig; Kelsie Cassell
Journal:  Int J Environ Res Public Health       Date:  2022-02-22       Impact factor: 3.390
  5 in total

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