Timothy C Durazzo1, Dieter J Meyerhoff2, Karmen K Yoder3, Donna E Murray2. 1. Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, United States; Mental Illness Research and Education Clinical Centers and Sierra-Pacific War Related Illness and Injury Study Center, VA Palo Alto Health Care System, United States. Electronic address: tdurazzo@stanford.edu. 2. Department of Radiology and Biomedical Imaging, University of California, San Francisco, United States; Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, United States. 3. Indiana University Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, United States.
Abstract
BACKGROUND: Magnetic resonance imaging studies of cigarette smoking-related effects on human brain structure have primarily employed voxel-based morphometry, and the most consistently reported finding was smaller volumes or lower density in anterior frontal regions and the insula. Much less is known about the effects of smoking on subcortical regions. We compared smokers and non-smokers on regional subcortical volumes, and predicted that smokers demonstrate greater age-related volume loss across subcortical regions than non-smokers. METHODS: Non-smokers (n=43) and smokers (n=40), 22-70 years of age, completed a 4T MRI study. Bilateral total subcortical lobar white matter (WM) and subcortical nuclei volumes were quantitated via FreeSurfer. In smokers, associations between smoking severity measures and subcortical volumes were examined. RESULTS: Smokers demonstrated greater age-related volume loss than non-smokers in the bilateral subcortical lobar WM, thalamus, and cerebellar cortex, as well as in the corpus callosum and subdivisions. In smokers, higher pack-years were associated with smaller volumes of the bilateral amygdala, nucleus accumbens, total corpus callosum and subcortical WM. CONCLUSIONS: Results provide novel evidence that chronic smoking in adults is associated with accelerated age-related volume loss in subcortical WM and GM nuclei. Greater cigarette quantity/exposure was related to smaller volumes in regions that also showed greater age-related volume loss in smokers. Findings suggest smoking adversely affected the structural integrity of subcortical brain regions with increasing age and exposure. The greater age-related volume loss in smokers may have implications for cortical-subcortical structural and/or functional connectivity, and response to available smoking cessation interventions. Published by Elsevier B.V.
BACKGROUND: Magnetic resonance imaging studies of cigarette smoking-related effects on human brain structure have primarily employed voxel-based morphometry, and the most consistently reported finding was smaller volumes or lower density in anterior frontal regions and the insula. Much less is known about the effects of smoking on subcortical regions. We compared smokers and non-smokers on regional subcortical volumes, and predicted that smokers demonstrate greater age-related volume loss across subcortical regions than non-smokers. METHODS: Non-smokers (n=43) and smokers (n=40), 22-70 years of age, completed a 4T MRI study. Bilateral total subcortical lobar white matter (WM) and subcortical nuclei volumes were quantitated via FreeSurfer. In smokers, associations between smoking severity measures and subcortical volumes were examined. RESULTS: Smokers demonstrated greater age-related volume loss than non-smokers in the bilateral subcortical lobar WM, thalamus, and cerebellar cortex, as well as in the corpus callosum and subdivisions. In smokers, higher pack-years were associated with smaller volumes of the bilateral amygdala, nucleus accumbens, total corpus callosum and subcortical WM. CONCLUSIONS: Results provide novel evidence that chronic smoking in adults is associated with accelerated age-related volume loss in subcortical WM and GM nuclei. Greater cigarette quantity/exposure was related to smaller volumes in regions that also showed greater age-related volume loss in smokers. Findings suggest smoking adversely affected the structural integrity of subcortical brain regions with increasing age and exposure. The greater age-related volume loss in smokers may have implications for cortical-subcortical structural and/or functional connectivity, and response to available smoking cessation interventions. Published by Elsevier B.V.
Entities:
Keywords:
Brain volume; Cigarette smoking; FreeSurfer; Magnetic resonance imaging; Subcortical; White matter
Authors: Valerie A Cardenas; Christina M Hough; Timothy C Durazzo; Dieter J Meyerhoff Journal: Alcohol Clin Exp Res Date: 2019-11-15 Impact factor: 3.455
Authors: Nathan Whitsel; Chandra A Reynolds; Erik J Buchholz; Shandell Pahlen; Rahul C Pearce; Sean N Hatton; Jeremy A Elman; Nathan A Gillespie; Daniel E Gustavson; Olivia K Puckett; Anders M Dale; Lisa T Eyler; Christine Fennema-Notestine; Donald J Hagler; Richard L Hauger; Linda K McEvoy; Ruth McKenzie; Michael C Neale; Matthew S Panizzon; Mark Sanderson-Cimino; Rosemary Toomey; Xin M Tu; Mc Kenna E Williams; Tyler Bell; Hong Xian; Michael J Lyons; William S Kremen; Carol E Franz Journal: Addiction Date: 2021-10-28 Impact factor: 6.526
Authors: Janie Corley; Simon R Cox; Sarah E Harris; Maria Valdéz Hernandez; Susana Muñoz Maniega; Mark E Bastin; Joanna M Wardlaw; John M Starr; Riccardo E Marioni; Ian J Deary Journal: Transl Psychiatry Date: 2019-10-07 Impact factor: 6.222
Authors: Stefanie L Kunas; Kevin Hilbert; Yunbo Yang; Jan Richter; Alfons Hamm; André Wittmann; Andreas Ströhle; Bettina Pfleiderer; Martin J Herrmann; Thomas Lang; Martin Lotze; Jürgen Deckert; Volker Arolt; Hans-Ulrich Wittchen; Benjamin Straube; Tilo Kircher; Alexander L Gerlach; Ulrike Lueken Journal: Soc Cogn Affect Neurosci Date: 2020-10-08 Impact factor: 3.436