OBJECTIVE: Our purpose was to examine the association between discordant growth and perinatal mortality and morbidity among twins with careful adjustment for maternal confounding factors. STUDY DESIGN: Two cohorts with and without chorionicity data were compared using generalized estimating modeling. RESULTS: Our population-based dataset consisted of 12,656 individual twins from whom 4% (452/12,656) had≥30% growth discordance. A subgroup of this population with chorionicity information had an incidence of 7.3%≥30% growth discordance. In growth-discordant twins, perinatal mortality and morbidity were higher than concordant pairs (P<0.01). Low Apgar score and perinatal mortality were more frequent in growth-discordant twins compared with growth-concordant ones (all P<0.01). CONCLUSION: Birth weight discordance (BWD) places twins at increased risk of perinatal mortality. Growth discordance was also an independent risk factor for lower Apgar score of 5 min less than 5.
OBJECTIVE: Our purpose was to examine the association between discordant growth and perinatal mortality and morbidity among twins with careful adjustment for maternal confounding factors. STUDY DESIGN: Two cohorts with and without chorionicity data were compared using generalized estimating modeling. RESULTS: Our population-based dataset consisted of 12,656 individual twins from whom 4% (452/12,656) had≥30% growth discordance. A subgroup of this population with chorionicity information had an incidence of 7.3%≥30% growth discordance. In growth-discordant twins, perinatal mortality and morbidity were higher than concordant pairs (P<0.01). Low Apgar score and perinatal mortality were more frequent in growth-discordant twins compared with growth-concordant ones (all P<0.01). CONCLUSION: Birth weight discordance (BWD) places twins at increased risk of perinatal mortality. Growth discordance was also an independent risk factor for lower Apgar score of 5 min less than 5.
Authors: Melissa M Amyx; Paul S Albert; Alaina M Bever; Stefanie N Hinkle; John Owen; William A Grobman; Roger B Newman; Edward K Chien; Robert E Gore-Langton; Germaine M Buck Louis; Katherine L Grantz Journal: Am J Obstet Gynecol Date: 2019-08-24 Impact factor: 8.661
Authors: Melissa M Amyx; Paul S Albert; Alaina M Bever; Stefanie N Hinkle; John Owen; William A Grobman; Roger B Newman; Edward K Chien; Robert E Gore-Langton; Germaine M Buck Louis; Katherine L Grantz Journal: Paediatr Perinat Epidemiol Date: 2019-09-03 Impact factor: 3.103
Authors: Ettore Piro; Ingrid Anne Mandy Schierz; Gregorio Serra; Giuseppe Puccio; Mario Giuffrè; Giovanni Corsello Journal: Ital J Pediatr Date: 2020-05-24 Impact factor: 2.638