Xing-Bo Mo1,2, Long-Fei Wu1,2, Xiao-Wei Zhu1,2, Wei Xia1,2, Lan Wang1,2, Pei He1,2, Peng-Fei Bing1,2, Xin Lu1,2, Yong-Hong Zhang2, Fei-Yan Deng1,2, Shu-Feng Lei1,2. 1. Center for Genetic Epidemiology & Genomics, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu 215123, PR China. 2. Jiangsu Key Laboratory of Preventive & Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, Jiangsu 215123, PR China.
Abstract
AIM: To identify sets of functionally related long noncoding RNAs (lncRNAs) and mRNAs and to evaluate the importance of lncRNAs in an lncRNA-mRNA network. METHODS: We carried out weighted gene co-expression network analysis and enrichment analyses to identify functional modules of co-expressed lncRNAs and mRNAs in human peripheral blood mononuclear cells of 43 females. RESULTS: We identified seven modules and found hub lncRNAs in each module. Four of the seven modules had significant gene ontology enrichments. Some of the hub lncRNAs (e.g., SSX8, UCA1, HOXA-AS2, STARD4-AS1 and PCBP1-AS1) have known functions related with diseases such as cancers. CONCLUSION: We identified seven biologically important lncRNA and mRNA integrative modules in females and showed that lncRNAs might play important roles in lncRNA-mRNA co-expression modules.
AIM: To identify sets of functionally related long noncoding RNAs (lncRNAs) and mRNAs and to evaluate the importance of lncRNAs in an lncRNA-mRNA network. METHODS: We carried out weighted gene co-expression network analysis and enrichment analyses to identify functional modules of co-expressed lncRNAs and mRNAs in human peripheral blood mononuclear cells of 43 females. RESULTS: We identified seven modules and found hub lncRNAs in each module. Four of the seven modules had significant gene ontology enrichments. Some of the hub lncRNAs (e.g., SSX8, UCA1, HOXA-AS2, STARD4-AS1 and PCBP1-AS1) have known functions related with diseases such as cancers. CONCLUSION: We identified seven biologically important lncRNA and mRNA integrative modules in females and showed that lncRNAs might play important roles in lncRNA-mRNA co-expression modules.