| Literature DB >> 28620993 |
Natalie E Doody1, Monika M Dowejko1, Elizabeth C Akam1, Nick J Cox1, Jasvinder S Bhatti2, Puneetpal Singh3, Sarabjit S Mastana1.
Abstract
This study investigated the role of IL-1β-511 (rs16944), TLR4-896 (rs4986790) and TNF-α-308 (rs1800629) polymorphisms in type 2 diabetes mellitus (T2DM) among an endogamous Northern Indian population. Four hundred fourteen participants (204 T2DM patients and 210 nondiabetic controls) were genotyped for IL-1β-511, TLR4-896 and TNF-α-308 loci. The C allele of IL-1β-511 was shown to increase T2DM susceptibility by 75% (OR: 1.75 [CI 1.32-2.33]). Having two parents affected by T2DM increased susceptibility by 5.7 times (OR: 5.693 [CI 1.431-22.648]). In this study, we have demonstrated a conclusive association with IL-1β-511 locus and IL-1β-511-TLR4-896 diplotype (CC-AA) and T2DM, which warrants further comprehensive analyses in larger cohorts.Entities:
Keywords: IL-1β-511; Inflammatory gene polymorphisms; North Indian population; TLR4 896; TNF-α-308; Type 2 diabetes mellitus
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Year: 2017 PMID： 28620993 DOI： 10.1111/ahg.12197
Source DB: PubMed Journal: Ann Hum Genet ISSN： 0003-4800 Impact factor: 1.670