Philip J Mease1,2, Chitra Karki3,4, Jacqueline B Palmer3,4, Carol J Etzel3,4, Arthur Kavanaugh3,4, Christopher T Ritchlin3,4, Wendi Malley3,4, Vivian Herrera3,4, Melody Tran3,4, Jeffrey D Greenberg3,4. 1. From the Swedish Medical Center and University of Washington (UW) Medicine, Seattle, Washington; Corrona LLC, Southborough, Massachusetts; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey; The University of Texas MD Anderson Cancer Center, Houston, Texas; University of California (UC) at San Diego, La Jolla, California; University of Rochester Medical Center, Rochester; New York University (NYU) School of Medicine, New York, New York; Scott and White Health Plan, Temple, Texas, USA. pmease@philipmease.com. 2. P.J. Mease, MD, Swedish Medical Center and UW Medicine; C. Karki, MPH, Corrona LLC; J.B. Palmer, PharmD, Novartis Pharmaceuticals Corporation; C.J. Etzel, PhD, Corrona LLC, and The University of Texas MD Anderson Cancer Center; A. Kavanaugh, MD, UC San Diego; C.T. Ritchlin, MD, University of Rochester Medical Center; W. Malley, MS, Corrona LLC; V. Herrera, DDS, Novartis Pharmaceuticals Corporation; M. Tran, PharmD, Scott and White Health Plan; J.D. Greenberg, MD, Corrona LLC, and NYU School of Medicine. pmease@philipmease.com. 3. From the Swedish Medical Center and University of Washington (UW) Medicine, Seattle, Washington; Corrona LLC, Southborough, Massachusetts; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey; The University of Texas MD Anderson Cancer Center, Houston, Texas; University of California (UC) at San Diego, La Jolla, California; University of Rochester Medical Center, Rochester; New York University (NYU) School of Medicine, New York, New York; Scott and White Health Plan, Temple, Texas, USA. 4. P.J. Mease, MD, Swedish Medical Center and UW Medicine; C. Karki, MPH, Corrona LLC; J.B. Palmer, PharmD, Novartis Pharmaceuticals Corporation; C.J. Etzel, PhD, Corrona LLC, and The University of Texas MD Anderson Cancer Center; A. Kavanaugh, MD, UC San Diego; C.T. Ritchlin, MD, University of Rochester Medical Center; W. Malley, MS, Corrona LLC; V. Herrera, DDS, Novartis Pharmaceuticals Corporation; M. Tran, PharmD, Scott and White Health Plan; J.D. Greenberg, MD, Corrona LLC, and NYU School of Medicine.
Abstract
OBJECTIVE: Psoriatic arthritis (PsA) is commonly comorbid with psoriasis; the extent of skin lesions is a major contributor to psoriatic disease severity/burden. We evaluated whether extent of skin involvement with psoriasis [body surface area (BSA) > 3% vs ≤ 3%] affects overall clinical and patient-reported outcomes (PRO) in patients with PsA. METHODS: Using the Corrona PsA/Spondyloarthritis Registry, patient characteristics, disease activity, and PRO at registry enrollment were assessed for patients with PsA aged ≥ 18 years with BSA > 3% versus ≤ 3%. Regression models were used to evaluate associations of BSA level with outcome [modified minimal disease activity (MDA), Health Assessment Questionnaire (HAQ) score, patient-reported pain and fatigue, and the Work Productivity and Activity Impairment questionnaire score]. Adjustments were made for age, sex, race, body mass index, disease duration, and history of biologics, disease-modifying antirheumatic drug, and prednisone use. RESULTS: This analysis included 1240 patients with PsA with known BSA level (n = 451, BSA > 3%; n = 789, BSA ≤ 3%). After adjusting for potential confounding variables, patients with BSA > 3% versus ≤ 3% had greater patient-reported pain and fatigue and higher HAQ scores (p = 2.33 × 10-8, p = 0.002, and p = 1.21 × 10-7, respectively), were 1.7× more likely not to be in modified MDA (95% CI 1.21-2.41, p = 0.002), and were 2.1× more likely to have overall work impairment (1.37-3.21, p = 0.0001). CONCLUSION: These Corrona Registry data show that substantial skin involvement (BSA > 3%) is associated with greater PsA disease burden, underscoring the importance of assessing and effectively managing psoriasis in patients with PsA because this may be a contributing factor in PsA severity.
OBJECTIVE:Psoriatic arthritis (PsA) is commonly comorbid with psoriasis; the extent of skin lesions is a major contributor to psoriatic disease severity/burden. We evaluated whether extent of skin involvement with psoriasis [body surface area (BSA) > 3% vs ≤ 3%] affects overall clinical and patient-reported outcomes (PRO) in patients with PsA. METHODS: Using the Corrona PsA/Spondyloarthritis Registry, patient characteristics, disease activity, and PRO at registry enrollment were assessed for patients with PsA aged ≥ 18 years with BSA > 3% versus ≤ 3%. Regression models were used to evaluate associations of BSA level with outcome [modified minimal disease activity (MDA), Health Assessment Questionnaire (HAQ) score, patient-reported pain and fatigue, and the Work Productivity and Activity Impairment questionnaire score]. Adjustments were made for age, sex, race, body mass index, disease duration, and history of biologics, disease-modifying antirheumatic drug, and prednisone use. RESULTS: This analysis included 1240 patients with PsA with known BSA level (n = 451, BSA > 3%; n = 789, BSA ≤ 3%). After adjusting for potential confounding variables, patients with BSA > 3% versus ≤ 3% had greater patient-reported pain and fatigue and higher HAQ scores (p = 2.33 × 10-8, p = 0.002, and p = 1.21 × 10-7, respectively), were 1.7× more likely not to be in modified MDA (95% CI 1.21-2.41, p = 0.002), and were 2.1× more likely to have overall work impairment (1.37-3.21, p = 0.0001). CONCLUSION: These Corrona Registry data show that substantial skin involvement (BSA > 3%) is associated with greater PsA disease burden, underscoring the importance of assessing and effectively managing psoriasis in patients with PsA because this may be a contributing factor in PsA severity.
Entities:
Keywords:
BODY SURFACE AREA; BURDEN OF ILLNESS; OUTCOME ASSESSMENT; PRODUCTIVITY; PSORIASIS; PSORIATIC ARTHRITIS
Authors: Arthur Kavanaugh; Kim Papp; Alice B Gottlieb; Elke M G J de Jong; Soumya D Chakravarty; Shelly Kafka; Wayne Langholff; Kamyar Farahi; Bhaskar Srivastava; Jose U Scher Journal: BMC Rheumatol Date: 2018-09-29
Authors: Kim Wervers; Marijn Vis; Ilja Tchetveriko; Andreas H Gerards; Marc R Kok; Cathelijne W Y Appels; Wiebo L van der Graaff; Johannes H L M van Groenendael; Lindy-Anne Korswagen; Josien J Veris-van Dieren; Johanna M W Hazes; Jolanda J Luime Journal: Arthritis Care Res (Hoboken) Date: 2018-12 Impact factor: 4.794
Authors: Fazira R Kasiem; Marc R Kok; Jolanda J Luime; Ilja Tchetverikov; Kim Wervers; Lindy-Anne Korswagen; Nastasja H A M Denissen; Yvonne P M Goekoop-Ruiterman; Maikel van Oosterhout; Faouzia Fodili; Johanna M W Hazes; Marijn Vis Journal: Rheumatology (Oxford) Date: 2022-04-11 Impact factor: 7.580