Literature DB >> 28619537

Synthesis and biological evaluation of caffeic acid derivatives as potent inhibitors of α-MSH-stimulated melanogenesis.

Hyeju Jo1, Minho Choi1, Jaeuk Sim1, Mayavan Viji1, Siyuan Li1, Young Hee Lee1, Youngsoo Kim1, Seung-Yong Seo2, Yuanyuan Zhou3, Kiho Lee3, Wun-Jae Kim4, Jin Tae Hong1, Heesoon Lee1, Jae-Kyung Jung5.   

Abstract

We have disclosed our effort to develop caffeic acid derivatives as potent and non-toxic inhibitors of α-MSH-stimulated melanogenesis to treat pigmentation disorders and skin medication including a cosmetic skin-whitening agent. The SAR studies revealed that cyclohexyl ester and secondary amide derivatives of caffeic acid showed significant inhibitory activities.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Caffeamide; Caffeic acid; Melanogenesis; Skin whitening; α-MSH

Mesh：

Substances：

Year:  2017        PMID： 28619537     DOI： 10.1016/j.bmcl.2017.06.011

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

Review 1.  Topical treatment strategies to manipulate human skin pigmentation.

Authors:  Inbal Rachmin; Stephen M Ostrowski; Qing Yu Weng; David E Fisher
Journal:  Adv Drug Deliv Rev       Date:  2020-02-21       Impact factor: 15.470

2.  Bioevaluation and molecular docking analysis of novel phenylpropanoid derivatives as potent food preservative and anti-microbials.

Authors:  Shruti Ahlawat; Akshay Shankar; Amit Lather; Anurag Khatkar; Krishna Kant Sharma
Journal:  3 Biotech       Date:  2021-01-13       Impact factor: 2.406

3.  Nuclear Entry of CRTC1 as Druggable Target of Acquired Pigmentary Disorder.

Authors:  Cheong-Yong Yun; Seung Deok Hong; Young Hee Lee; Jiyeon Lee; Da-Eun Jung; Ga Hyun Kim; Song-Hee Kim; Jae-Kyung Jung; Ki Ho Kim; Heesoon Lee; Jin Tae Hong; Sang-Bae Han; Youngsoo Kim
Journal:  Theranostics       Date:  2019-01-21       Impact factor: 11.556

4.  A Straightforward Access to New Amides of the Melanin Precursor 5,6-Dihydroxyindole-2-carboxylic Acid and Characterization of the Properties of the Pigments Thereof.

Authors:  Rita Argenziano; Marina Della Greca; Lucia Panzella; Alessandra Napolitano
Journal:  Molecules       Date:  2022-07-27       Impact factor: 4.927

5.  Germinated Riceberry Rice Enhanced Protocatechuic Acid and Vanillic Acid to Suppress Melanogenesis through Cellular Oxidant-Related Tyrosinase Activity in B16 Cells.

Authors:  Teerapat Rodboon; Seiji Okada; Prasit Suwannalert
Journal:  Antioxidants (Basel)       Date:  2020-03-19

6.  Identification of Phytoconstituents as Potent Inhibitors of Casein Kinase-1 Alpha Using Virtual Screening and Molecular Dynamics Simulations.

Authors:  Alaa Shafie; Shama Khan; Taj Mohammad; Farah Anjum; Gulam Mustafa Hasan; Dharmendra Kumar Yadav; Md Imtaiyaz Hassan
Journal:  Pharmaceutics       Date:  2021-12-15       Impact factor: 6.321
  6 in total

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