Literature DB >> 28619004

Albumin Nanocarriers, γ- Irradiated Crosslinked, Combined with Therapeutic Drugs for Cancer Therapy>.

Macarena Siri1, Estefania Achilli2, Mariano Grasselli2, Silvia Del V Alonso1.   

Abstract

Albumin polymeric Nanoparticles (NPs) have opened a great expectancy as for controlled drug delivery due to their therapeutic potency. Concomitantly biodegradable NPs technologies with target linked structures to pave the way of personalised medicine are becoming increasingly important in sight of a therapeutically effective research technology. This is particularly attractive for nanoparticle-based cancer delivery systems, based on the known limitations and efforts to overcome. This new group of gamma irradiated-NPs inherited both the protein delivery properties and robustness of polymer forming structures, and gamma irradiation techniques that leave clean, innocuous and biodegradable NPs. These protein NPs made of serum albumin are referred to SA NPs that possesses several characteristics making them especially attractive to be considered as a drug delivery system. This review focused on methodologies actually being used in the synthesis and characterisation of albumin NPs and different author's opinions on strategic ways to treat cancerous cell-lines with NPs. Utterly, challenges being overthrown by researchers are brought up to anneal an effective, all in one targeted albumin NPs to passed through in vitro and preclinical trials. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  Albumin; NPs; cancer cell-lines; desolvation.; radiation-induced crosslinking; therapeutic-drugs

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Year:  2017        PMID: 28619004     DOI: 10.2174/1381612823666170615105909

Source DB:  PubMed          Journal:  Curr Pharm Des        ISSN: 1381-6128            Impact factor:   3.116


  2 in total

Review 1.  IAEA Contribution to Nanosized Targeted Radiopharmaceuticals for Drug Delivery.

Authors:  Amir R Jalilian; Blanca Ocampo-García; Wanvimol Pasanphan; Tamer M Sakr; Laura Melendez-Alafort; Mariano Grasselli; Ademar B Lugao; Hassan Yousefnia; Clelia Dispenza; Siti Mohd Janib; Irfan U Khan; Michał Maurin; Piotr Ulański; Say Chye Joachim Loo; Agnes Safrany; Joao A Osso; Adriano Duatti; Kattesh V Katti
Journal:  Pharmaceutics       Date:  2022-05-15       Impact factor: 6.525

Review 2.  Polymer-based nanoparticles: fabrication to applications-the many faces of DC8,9PC and albumin.

Authors:  M Grasselli; Silvia Del V Alonso
Journal:  Biophys Rev       Date:  2021-11-20
  2 in total

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