J-S Zhang1, L-Q Yang, B-R Du, H Gao. 1. Department of Medical Imaging, Linyi People's Hospital, Linyi, Shandong, China. zjszm456@163.com.
Abstract
OBJECTIVE: The aim of the present study was to clarify the expression pattern and prognostic role of RABEX-5 mRNA in colorectal cancer (CRC) patients. PATIENTS AND METHODS: RABEX-5 mRNA levels in 187 CRC were examined by Real-time polymerase chain reaction. Then, the association of RABEX-5 mRNA levels with clinicopathological features was analyzed. Survival curves were plotted using the Kaplan-Meier method and differences in survival rates were analyzed using the log-rank test. The influence of each variable on survival was examined by the Cox multivariate regression analysis. RESULTS: RABEX-5 mRNA expression was significantly upregulated in CRC tissues compared with the adjacent noncancerous tissues (p < 0.01). By statistical analyses, high RABEX-5 mRNA expression was observed to be closely correlated with histology/differentiation (p = 0.010), N classification (p = 0.004), and TNM stage (p = 0.004). Kaplan-Meier curves showed that patients with high RABEX-5 mRNA expression showed unfavorable overall survival (OS) than the low RABEX-5 mRNA expression group (p < 0.001). Finally, univariate and multivariate analyses showed that RABEX-5 mRNA expression was an independent predictor of overall survival (p < 0.05). CONCLUSIONS: RABEX-5 mRNA may be a promising biomarker for the detection and prognosis evaluation of CRC.
OBJECTIVE: The aim of the present study was to clarify the expression pattern and prognostic role of RABEX-5 mRNA in colorectal cancer (CRC) patients. PATIENTS AND METHODS: RABEX-5 mRNA levels in 187 CRC were examined by Real-time polymerase chain reaction. Then, the association of RABEX-5 mRNA levels with clinicopathological features was analyzed. Survival curves were plotted using the Kaplan-Meier method and differences in survival rates were analyzed using the log-rank test. The influence of each variable on survival was examined by the Cox multivariate regression analysis. RESULTS:RABEX-5 mRNA expression was significantly upregulated in CRC tissues compared with the adjacent noncancerous tissues (p < 0.01). By statistical analyses, high RABEX-5 mRNA expression was observed to be closely correlated with histology/differentiation (p = 0.010), N classification (p = 0.004), and TNM stage (p = 0.004). Kaplan-Meier curves showed that patients with high RABEX-5 mRNA expression showed unfavorable overall survival (OS) than the low RABEX-5 mRNA expression group (p < 0.001). Finally, univariate and multivariate analyses showed that RABEX-5 mRNA expression was an independent predictor of overall survival (p < 0.05). CONCLUSIONS:RABEX-5 mRNA may be a promising biomarker for the detection and prognosis evaluation of CRC.
Authors: Solange Rivas; Patricio Silva; Montserrat Reyes; Hugo Sepúlveda; Luis Solano; Juan Acuña; Marisol Guerrero; Manuel Varas-Godoy; Andrew F G Quest; Martín Montecino; Vicente A Torres Journal: Sci Rep Date: 2020-12-18 Impact factor: 4.379