B Brotschi1, R Gunny2, C Rethmann3, U Held4, B Latal5, C Hagmann6. 1. Department of Pediatric and Neonatal Intensive Care, University Children's Hospital Zurich, Zurich, Switzerland. 2. Department of Pediatric Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. 3. Department of Radiology, University Children's Hospital Zurich, Zurich, Switzerland. 4. Horten Centre for Patient Oriented Research and Knowledge Transfer, University Hospital Zurich, Zurich, Switzerland. 5. Child Development Center, University Children's Hospital Zurich, Zurich, Switzerland. 6. Department of Neonatology, University Hospital Zurich, Zurich, Switzerland.
Abstract
OBJECTIVE: The objective of the study was whether temperature management during therapeutic hypothermia correlates with the severity of brain injury assessed on magnetic resonance imaging in term infants with hypoxic-ischemic encephalopathy. STUDY DESIGN: Prospectively collected register data from the National Asphyxia and Cooling Register of Switzerland were analyzed. RESULT: Fifty-five newborn infants were cooled for 72 h with a target temperature range of 33 to 34 °C. Individual temperature variability (odds ratio (OR) 40.17 (95% confidence interval (CI) 1.37 to 1037.67)) and percentage of temperatures within the target range (OR 0.95 (95% CI 0.90 to 0.98)) were associated with the severity of brain injury seen on magnetic resonance imaging (MRI). Neither the percentage of measured temperatures above (OR 1.08 (95% CI 0.96 to 1.21)) nor below (OR 0.99 (95% CI 0.92 to 1.07) the target range was associated with the severity of brain injury seen on MRI. CONCLUSION: In a national perinatal asphyxia cohort, temperature variability and percentage of temperatures within the target temperature range were associated with the severity of brain injury.
OBJECTIVE: The objective of the study was whether temperature management during therapeutic hypothermia correlates with the severity of brain injury assessed on magnetic resonance imaging in term infants with hypoxic-ischemicencephalopathy. STUDY DESIGN: Prospectively collected register data from the National Asphyxia and Cooling Register of Switzerland were analyzed. RESULT: Fifty-five newborn infants were cooled for 72 h with a target temperature range of 33 to 34 °C. Individual temperature variability (odds ratio (OR) 40.17 (95% confidence interval (CI) 1.37 to 1037.67)) and percentage of temperatures within the target range (OR 0.95 (95% CI 0.90 to 0.98)) were associated with the severity of brain injury seen on magnetic resonance imaging (MRI). Neither the percentage of measured temperatures above (OR 1.08 (95% CI 0.96 to 1.21)) nor below (OR 0.99 (95% CI 0.92 to 1.07) the target range was associated with the severity of brain injury seen on MRI. CONCLUSION: In a national perinatal asphyxia cohort, temperature variability and percentage of temperatures within the target temperature range were associated with the severity of brain injury.
Authors: Seetha Shankaran; Abbot R Laptook; Scott A McDonald; Rosemary D Higgins; Jon E Tyson; Richard A Ehrenkranz; Abhik Das; Guilherme Sant'Anna; Ronald N Goldberg; Rebecca Bara; Michele C Walsh Journal: Pediatr Crit Care Med Date: 2012-01 Impact factor: 3.624
Authors: Barbara Brotschi; Beate Grass; Gabriel Ramos; Ingrid Beck; Ulrike Held; Cornelia Hagmann; Ph Meyer; G Zeilinger; S M Schulzke; S Wellmann; B Wagner; K Daetwyler; M Nelle; W Bär; B Scharrer; J-F Tolsa; A Truttmann; J Schneider; R E Pfister; T M Berger; M Fontana; J P Micallef; A Birkenmayer; H U Bucher; G Natalucci; M Adams; B Frey; V Bernet; B Latal Journal: Early Hum Dev Date: 2015-03-10 Impact factor: 2.079
Authors: Subrata Sarkar; Steven M Donn; Jayapalli R Bapuraj; Indira Bhagat; John D Barks Journal: Arch Dis Child Fetal Neonatal Ed Date: 2012-09 Impact factor: 5.747
Authors: Abbot Laptook; Jon Tyson; Seetha Shankaran; Scott McDonald; Richard Ehrenkranz; Avroy Fanaroff; Edward Donovan; Ronald Goldberg; T Michael O'Shea; Rosemary D Higgins; W Kenneth Poole Journal: Pediatrics Date: 2008-09 Impact factor: 7.124
Authors: Abbot R Laptook; Scott A McDonald; Seetha Shankaran; Bonnie E Stephens; Betty R Vohr; Ronnie Guillet; Rosemary D Higgins; Abhik Das Journal: Ann Neurol Date: 2013-04-17 Impact factor: 10.422
Authors: M A Rutherford; J M Pennock; S J Counsell; E Mercuri; F M Cowan; L M Dubowitz; A D Edwards Journal: Pediatrics Date: 1998-08 Impact factor: 7.124