Literature DB >> 2861730

Pharmacological profile of mifentidine: a novel H2-receptor antagonist.

A Giachetti, F Pagani, R Micheletti, A Brambilla, E Cereda, A Donetti.   

Abstract

Mifentidine, a representative compound of a novel class of H2-antagonists, has been investigated for its ability to interact with H2-receptors and to inhibit gastric acid secretion. Affinity estimates (KB) of mifentidine obtained from in vitro studies on cardiac and gastric mucosal histamine (H2) receptors were in the 20-50 nM range. Mifentidine appeared to be endowed with strong anti-secretory properties against histamine-stimulated secretion in the anaesthetized rat and in the conscious dog. Distinct features of mifentidine were considerable bioavailability and duration of anti-secretory effect.

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Year:  1985        PMID： 2861730     DOI： 10.1007/bf01983131

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  4 in total

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Journal:  Anal Biochem       Date:  1974-04       Impact factor: 3.365

2.  Some quantitative uses of drug antagonists.

Authors:  O ARUNLAKSHANA; H O SCHILD
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Authors:  G Bertaccini; E Poli; G Coruzzi
Journal:  Agents Actions       Date:  1984-04

4.  (Imidazolylphenyl)formamidines. A structurally novel class of potent histamine H2 receptor antagonists.

Authors:  A Donetti; E Cereda; E Bellora; A Gallazzi; C Bazzano; P Vanoni; P Del Soldato; R Micheletti; F Pagani; A Giachetti
Journal:  J Med Chem       Date:  1984-03       Impact factor: 7.446
  4 in total
  6 in total

1.  Pharmacokinetics of mifentidine after single and multiple oral administration to healthy volunteers.

Authors:  B P Imbimbo; R Urso; G Thieme; B Sturn; B Ueckert; A Vidi; H Ladinsky; S Daniotti
Journal:  Br J Clin Pharmacol       Date:  1988-10       Impact factor: 4.335

2.  Mechanism of action of H2-antagonists on histamine- or dimaprit-stimulated H2-receptors of spontaneously beating guinea-pig atrium.

Authors:  M J Krielaart; D M Veenstra; K J van Buuren
Journal:  Agents Actions       Date:  1990-08

3.  Evaluation of novel compounds interacting with H2-histamine receptors: effect on histamine-sensitive adenylate cyclase activity in guinea-pig gastric mucosa.

Authors:  R Micheletti; D Oliva; P Belfiore; A Giachetti; S Nicosia
Journal:  Agents Actions       Date:  1985-07

4.  Action of mifentidine on the secretory response to sham feeding and pentagastrin and on serum gastrin in duodenal ulcer patients.

Authors:  G Bianchi Porro; M Lazzaroni; B P Imbimbo; O Sangaletti; C Ghirardosi; S Daniotti
Journal:  Eur J Clin Pharmacol       Date:  1987       Impact factor: 2.953

5.  Kinetic analysis of the interaction of mifentidine with gastric H2-receptors in the conscious dog.

Authors:  F Pagani; M Zecca; A Giachetti
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-09       Impact factor: 3.000

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Authors:  Mark K Bakker; Rick A A van der Spek; Wouter van Rheenen; Sandrine Morel; Romain Bourcier; Isabel C Hostettler; Varinder S Alg; Kristel R van Eijk; Masaru Koido; Masato Akiyama; Chikashi Terao; Koichi Matsuda; Robin G Walters; Kuang Lin; Liming Li; Iona Y Millwood; Zhengming Chen; Guy A Rouleau; Sirui Zhou; Kristiina Rannikmäe; Cathie L M Sudlow; Henry Houlden; Leonard H van den Berg; Christian Dina; Olivier Naggara; Jean-Christophe Gentric; Eimad Shotar; François Eugène; Hubert Desal; Bendik S Winsvold; Sigrid Børte; Marianne Bakke Johnsen; Ben M Brumpton; Marie Søfteland Sandvei; Cristen J Willer; Kristian Hveem; John-Anker Zwart; W M Monique Verschuren; Christoph M Friedrich; Sven Hirsch; Sabine Schilling; Jérôme Dauvillier; Olivier Martin; Gregory T Jones; Matthew J Bown; Nerissa U Ko; Helen Kim; Jonathan R I Coleman; Gerome Breen; Jonathan G Zaroff; Catharina J M Klijn; Rainer Malik; Martin Dichgans; Muralidharan Sargurupremraj; Turgut Tatlisumak; Philippe Amouyel; Stéphanie Debette; Gabriel J E Rinkel; Bradford B Worrall; Joanna Pera; Agnieszka Slowik; Emília I Gaál-Paavola; Mika Niemelä; Juha E Jääskeläinen; Mikael von Und Zu Fraunberg; Antti Lindgren; Joseph P Broderick; David J Werring; Daniel Woo; Richard Redon; Philippe Bijlenga; Yoichiro Kamatani; Jan H Veldink; Ynte M Ruigrok
Journal:  Nat Genet       Date:  2020-11-16       Impact factor: 41.307
  6 in total

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