Literature DB >> 28616589

miR-145: Revival of a Dragon in Pancreatic Cancer.

Saini Setua1, Sheema Khan1, Kyle Doxtater1, Murali M Yallapu1, Meena Jaggi1, Subhash C Chauhan1.   

Abstract

Emergence of the role of MicroRNA-145 (miR-145) as a tumor suppressor in pancreatic cancer, offers its potential for novel therapeutic interventions. Our recently published studies demonstrate clinical significance of miR-145 in pancreatic cancer and suggest that the dysregulation of miR-145 in human pancreatic tumors draws in parallel with the aberrant expression of an oncogenic mucin, MUC13. These studies also present a novel therapeutic strategy of restoring the downregulated levels of miR-145 in pancreatic cancer via nanoparticle mediated efficient delivery system.

Entities:  

Keywords:  MUC13; Nanoparticles; Pancreatic cancer; Tumor suppressor; microRNA-145

Year:  2017        PMID： 28616589      PMCID： PMC5467535     

Source DB:  PubMed          Journal:  J Nat Sci        ISSN： 2377-2700


  12 in total

1.  MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1.

Authors:  Mohit Sachdeva; Yin-Yuan Mo
Journal:  Cancer Res       Date:  2009-12-08       Impact factor: 12.701

2.  miR145 targets the SOX9/ADAM17 axis to inhibit tumor-initiating cells and IL-6-mediated paracrine effects in head and neck cancer.

Authors:  Cheng-Chia Yu; Lo-Lin Tsai; Mong-Lien Wang; Chuan-Hang Yu; Wen-Liang Lo; Yun-Ching Chang; Guang-Yuh Chiou; Ming-Yung Chou; Shih-Hwa Chiou
Journal:  Cancer Res       Date:  2013-04-02       Impact factor: 12.701

3.  miR-145 suppresses thyroid cancer growth and metastasis and targets AKT3.

Authors:  Myriem Boufraqech; Lisa Zhang; Meenu Jain; Dhaval Patel; Ryan Ellis; Yin Xiong; Mei He; Naris Nilubol; Maria J Merino; Electron Kebebew
Journal:  Endocr Relat Cancer       Date:  2014-04-29       Impact factor: 5.678

4.  miRNA-145 inhibits non-small cell lung cancer cell proliferation by targeting c-Myc.

Authors:  Zhe Chen; Huazong Zeng; Yong Guo; Pei Liu; Hui Pan; Anmei Deng; Jian Hu
Journal:  J Exp Clin Cancer Res       Date:  2010-11-22

5.  Novel curcumin-loaded magnetic nanoparticles for pancreatic cancer treatment.

Authors:  Murali M Yallapu; Mara C Ebeling; Sheema Khan; Vasudha Sundram; Neeraj Chauhan; Brij K Gupta; Susan E Puumala; Meena Jaggi; Subhash C Chauhan
Journal:  Mol Cancer Ther       Date:  2013-05-23       Impact factor: 6.261

6.  Restitution of Tumor Suppressor MicroRNA-145 Using Magnetic Nanoformulation for Pancreatic Cancer Therapy.

Authors:  Saini Setua; Sheema Khan; Murali M Yallapu; Stephen W Behrman; Mohammed Sikander; Shabia Shabir Khan; Meena Jaggi; Subhash C Chauhan
Journal:  J Gastrointest Surg       Date:  2016-08-09       Impact factor: 3.452

7.  MiR-145 directly targets p70S6K1 in cancer cells to inhibit tumor growth and angiogenesis.

Authors:  Qing Xu; Ling-Zhi Liu; Xu Qian; Qi Chen; Yue Jiang; Dan Li; Lihui Lai; Bing-Hua Jiang
Journal:  Nucleic Acids Res       Date:  2011-09-14       Impact factor: 16.971

8.  MicroRNA-145 targets MUC13 and suppresses growth and invasion of pancreatic cancer.

Authors:  Sheema Khan; Mara C Ebeling; Mohd S Zaman; Mohammed Sikander; Murali M Yallapu; Neeraj Chauhan; Ashley M Yacoubian; Stephen W Behrman; Nadeem Zafar; Deepak Kumar; Paul A Thompson; Meena Jaggi; Subhash C Chauhan
Journal:  Oncotarget       Date:  2014-09-15

Review 9.  MicroRNA-145: a potent tumour suppressor that regulates multiple cellular pathways.

Authors:  Shi-Yun Cui; Rui Wang; Long-Bang Chen
Journal:  J Cell Mol Med       Date:  2014-08-15       Impact factor: 5.310

Review 10.  MicroRNA Targeted Therapeutic Approach for Pancreatic Cancer.

Authors:  Yiwei Li; Fazlul H Sarkar
Journal:  Int J Biol Sci       Date:  2016-01-28       Impact factor: 6.580
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  2 in total

Review 1.  Mesenchymal stem cell (MSC)-derived exosomes as novel vehicles for delivery of miRNAs in cancer therapy.

Authors:  Behnoush Sohrabi; Behnaz Dayeri; Elahe Zahedi; Shahrouz Khoshbakht; Najme Nezamabadi Pour; Hamta Ranjbar; Abolfazl Davari Nejad; Mahdi Noureddini; Behrang Alani
Journal:  Cancer Gene Ther       Date:  2022-01-26       Impact factor: 5.854

Review 2.  MicroRNAs Targeting MYC Expression: Trace of Hope for Pancreatic Cancer Therapy. A Systematic Review.

Authors:  Roshanak Shams; Hamid Asadzadeh Aghdaei; Ali Behmanesh; Amir Sadeghi; Mohammadareza Zali; Sina Salari; José M Padrón
Journal:  Cancer Manag Res       Date:  2020-04-01       Impact factor: 3.989
  2 in total

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