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Literature DB >> 28616583

MNK inversely regulates TELO2 vs. DEPTOR to control mTORC1 signaling.

Abstract

mTORC1 is the major homeostatic nutrient sensor for the cell. As such, it is integrated into diverse signaling networks and co-factor interactions that determine its activity. Our recent work implicates the mTORC1 co-factor and PI3K-related Kinase (PIKK) stabilizer, TELO2, in regulating mTORC1 activity in a MAPK-Interacting Kinase (MNK) responsive manner during mitogenic stimulation of cancer cells and T cell activation.

Entities: Disease Gene

Keywords: DDB1; DEPTOR; MNK; TELO2; mTOR

Year: 2017 PMID： 28616583 PMCID： PMC5462518 DOI： 10.1080/23723556.2017.1306010

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

10 in total

Review 1. mTOR signaling in growth control and disease.

Authors: Mathieu Laplante; David M Sabatini
Journal: Cell Date: 2012-04-13 Impact factor: 41.582

2. MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.

Authors: Michal Grzmil; Roland M Huber; Daniel Hess; Stephan Frank; Debby Hynx; Gerald Moncayo; Dominique Klein; Adrian Merlo; Brian A Hemmings
Journal: J Clin Invest Date: 2014-01-09 Impact factor: 14.808

3. Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development.

Authors: Takeshi Ueda; Masato Sasaki; Andrew J Elia; Iok In Christine Chio; Koichi Hamada; Rikiro Fukunaga; Tak W Mak
Journal: Proc Natl Acad Sci U S A Date: 2010-08-02 Impact factor: 11.205

4. Induction of viral, 7-methyl-guanosine cap-independent translation and oncolysis by mitogen-activated protein kinase-interacting kinase-mediated effects on the serine/arginine-rich protein kinase.

Authors: Michael C Brown; Jeffrey D Bryant; Elena Y Dobrikova; Mayya Shveygert; Shelton S Bradrick; Vidyalakshmi Chandramohan; Darell D Bigner; Matthias Gromeier
Journal: J Virol Date: 2014-09-03 Impact factor: 5.103

Review 5. Oncolytic immunotherapy through tumor-specific translation and cytotoxicity of poliovirus.

Authors: Michael C Brown; Matthias Gromeier
Journal: Discov Med Date: 2015-05 Impact factor: 2.970

6. Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.

Authors: Michael C Brown; Mikhail I Dobrikov; Matthias Gromeier
Journal: J Virol Date: 2014-09-03 Impact factor: 5.103

7. Ubiquitin hydrolase UCH-L1 destabilizes mTOR complex 1 by antagonizing DDB1-CUL4-mediated ubiquitination of raptor.

Authors: Sajjad Hussain; Andrew L Feldman; Chittaranjan Das; Steven C Ziesmer; Stephen M Ansell; Paul J Galardy
Journal: Mol Cell Biol Date: 2013-01-07 Impact factor: 4.272

8. MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1.

Authors: Michael C Brown; Matthias Gromeier
Journal: Cell Rep Date: 2017-02-07 Impact factor: 9.423

9. Tel2 regulates the stability of PI3K-related protein kinases.

Authors: Hiroyuki Takai; Richard C Wang; Kaori K Takai; Haijuan Yang; Titia de Lange
Journal: Cell Date: 2007-12-28 Impact factor: 41.582

10. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer.

Authors: Arkaitz Carracedo; Li Ma; Julie Teruya-Feldstein; Federico Rojo; Leonardo Salmena; Andrea Alimonti; Ainara Egia; Atsuo T Sasaki; George Thomas; Sara C Kozma; Antonella Papa; Caterina Nardella; Lewis C Cantley; Jose Baselga; Pier Paolo Pandolfi
Journal: J Clin Invest Date: 2008-09 Impact factor: 14.808

10 in total

2 in total

1. Synergistic effects of inhibiting the MNK-eIF4E and PI3K/AKT/ mTOR pathways on cell migration in MDA-MB-231 cells.

Authors: Ella Lineham; Graham J Tizzard; Simon J Coles; John Spencer; Simon J Morley
Journal: Oncotarget Date: 2018-01-31

2. Galeterone and The Next Generation Galeterone Analogs, VNPP414 and VNPP433-3β Exert Potent Therapeutic Effects in Castration-/Drug-Resistant Prostate Cancer Preclinical Models In Vitro and In Vivo.

Authors: Andrew K Kwegyir-Afful; Senthilmurugan Ramalingam; Vidya P Ramamurthy; Puranik Purushottamachar; Francis N Murigi; Tadas S Vasaitis; Weiliang Huang; Maureen A Kane; Yuji Zhang; Nicholas Ambulos; Sudhir Tiwari; Pratima Srivastava; Ivo P Nnane; Arif Hussain; Yun Qiu; David J Weber; Vincent C O Njar
Journal: Cancers (Basel) Date: 2019-10-24 Impact factor: 6.639

2 in total