Literature DB >> 28616582

A new duet in cancer biology: AMPK the typical and UBE2O the atypical.

Isabelle K Vila1, Su Jung Song2, Min Sup Song1,3.   

Abstract

Ubiquitin-conjugating enzyme E2O (UBE2O) is upregulated in human cancers. We have demonstrated that genetic deletion or pharmacological blockade of UBE2O reduces tumorigenesis through inhibiting the mammalian target of rapamycin complex 1-hypoxia-inducible factor 1-α pathway. Critically, UBE2O targets adenosine monophosphate (AMP)-activated protein kinase-α 2 (AMPKα2) for ubiquitination and degradation. We thus suggest the UBE2O-AMPKα2 axis as a potential therapeutic target for cancer.

Entities:  

Keywords:  AMPK; AMPKα2; HIF1α; UBE2O; arsenite; breast cancer; cancer metabolism; mTOR; prostate cancer; ubiquitination

Year:  2017        PMID： 28616582      PMCID： PMC5462509          DOI： 10.1080/23723556.2017.1304846

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Ubiquitination in disease pathogenesis and treatment.

Authors:  Doris Popovic; Domagoj Vucic; Ivan Dikic
Journal:  Nat Med       Date:  2014-11-06       Impact factor: 53.440

Review 2.  Metformin: from mechanisms of action to therapies.

Authors:  Marc Foretz; Bruno Guigas; Luc Bertrand; Michael Pollak; Benoit Viollet
Journal:  Cell Metab       Date:  2014-10-30       Impact factor: 27.287

3.  A UBE2O-AMPKα2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy.

Authors:  Isabelle K Vila; Yixin Yao; Goeun Kim; Weiya Xia; Hyejin Kim; Sun-Joong Kim; Mi-Kyung Park; James P Hwang; Enrique González-Billalabeitia; Mien-Chie Hung; Su Jung Song; Min Sup Song
Journal:  Cancer Cell       Date:  2017-02-02       Impact factor: 31.743

4.  A novel, arsenite-sensitive E2 of the ubiquitin pathway: purification and properties.

Authors:  N S Klemperer; E S Berleth; C M Pickart
Journal:  Biochemistry       Date:  1989-07-11       Impact factor: 3.162

5.  Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6.

Authors:  Xiaofei Zhang; Juan Zhang; Andreas Bauer; Long Zhang; Douglas W Selinger; Chris X Lu; Peter Ten Dijke
Journal:  EMBO J       Date:  2013-03-01       Impact factor: 11.598

Review 6.  The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins.

Authors:  Sjoerd J L van Wijk; H T Marc Timmers
Journal:  FASEB J       Date:  2009-11-25       Impact factor: 5.191

7.  Mechanism of ubiquitin conjugating enzyme E2-230K: catalysis involving a thiol relay?

Authors:  E S Berleth; C M Pickart
Journal:  Biochemistry       Date:  1996-02-06       Impact factor: 3.162

Review 8.  AMPK: a contextual oncogene or tumor suppressor?

Authors:  Jiyong Liang; Gordon B Mills
Journal:  Cancer Res       Date:  2013-05-03       Impact factor: 12.701

9.  Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O.

Authors:  Nazar Mashtalir; Salima Daou; Haithem Barbour; Nadine N Sen; Jessica Gagnon; Ian Hammond-Martel; Haider H Dar; Marc Therrien; El Bachir Affar
Journal:  Mol Cell       Date:  2014-04-03       Impact factor: 17.970

10.  Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination.

Authors:  Yi-Heng Hao; Jennifer M Doyle; Saumya Ramanathan; Timothy S Gomez; Da Jia; Ming Xu; Zhijian J Chen; Daniel D Billadeau; Michael K Rosen; Patrick Ryan Potts
Journal:  Cell       Date:  2013-02-28       Impact factor: 41.582
  10 in total
  3 in total

1.  Ubiquitin-conjugating enzyme UBE2O regulates cellular clock function by promoting the degradation of the transcription factor BMAL1.

Authors:  Suping Chen; Jing Yang; Yang Zhang; Chunyan Duan; Qing Liu; Zhengyun Huang; Ying Xu; Liang Zhou; Guoqiang Xu
Journal:  J Biol Chem       Date:  2018-06-05       Impact factor: 5.157

2.  Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals.

Authors:  Monta Ustinova; Ivars Silamikelis; Ineta Kalnina; Laura Ansone; Vita Rovite; Ilze Elbere; Ilze Radovica-Spalvina; Davids Fridmanis; Jekaterina Aladyeva; Ilze Konrade; Valdis Pirags; Janis Klovins
Journal:  PLoS One       Date:  2019-11-08       Impact factor: 3.240

Review 3.  The role of ubiquitination and deubiquitination in cancer metabolism.

Authors:  Tianshui Sun; Zhuonan Liu; Qing Yang
Journal:  Mol Cancer       Date:  2020-10-01       Impact factor: 27.401
  3 in total

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