Literature DB >> 28616581

The enigma of RIPK1 in the liver: More than just a kinase.

Mihael Vucur1, Anne T Schneider1, Jérémie Gautheron1, Tom Luedde1.   

Abstract

Receptor interacting protein kinase 1 (RIPK1) represents a key molecule in cell death. Here, we discuss our recent data on RIPK1 in liver injury and hepatocellular carcinoma development and put these into relation to previous experimental findings to underpin that it exerts opposing kinase-dependent and kinase independent functions in liver cells.

Entities:  

Keywords:  APAP; Acetaminophen; ConA; HCC; RIP1; TRAF2; concanavalin A; hepatocarcinogenesis

Year:  2017        PMID： 28616581      PMCID： PMC5462506          DOI： 10.1080/23723556.2017.1304191

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

1.  IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1.

Authors:  Christiane Koppe; Patricia Verheugd; Jérémie Gautheron; Florian Reisinger; Karina Kreggenwinkel; Christoph Roderburg; Luca Quagliata; Luigi Terracciano; Nikolaus Gassler; René H Tolba; Yannick Boege; Achim Weber; Michael Karin; Mark Luedde; Ulf P Neumann; Ralf Weiskirchen; Frank Tacke; Mihael Vucur; Christian Trautwein; Bernhard Lüscher; Christian Preisinger; Mathias Heikenwalder; Tom Luedde
Journal:  Hepatology       Date:  2016-08-11       Impact factor: 17.425

2.  TRAF2 Sets a threshold for extrinsic apoptosis by tagging caspase-8 with a ubiquitin shutoff timer.

Authors:  Francois Gonzalvez; David Lawrence; Becky Yang; Sharon Yee; Robert Pitti; Scot Marsters; Victoria C Pham; Jean-Philippe Stephan; Jennie Lill; Avi Ashkenazi
Journal:  Mol Cell       Date:  2012-11-08       Impact factor: 17.970

3.  RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer.

Authors:  Anne T Schneider; Jérémie Gautheron; Maria Feoktistova; Christoph Roderburg; Sven H Loosen; Sanchari Roy; Fabian Benz; Peter Schemmer; Markus W Büchler; Ueli Nachbur; Ulf P Neumann; Rene Tolba; Mark Luedde; Jessica Zucman-Rossi; Diana Panayotova-Dimitrova; Martin Leverkus; Christian Preisinger; Frank Tacke; Christian Trautwein; Thomas Longerich; Mihael Vucur; Tom Luedde
Journal:  Cancer Cell       Date:  2016-12-22       Impact factor: 31.743

4.  Receptor interacting protein kinase 1 (RIPK1) in hepatocytes does not mediate murine acetaminophen toxicity.

Authors:  Anne T Schneider; Jérémie Gautheron; Frank Tacke; Mihael Vucur; Tom Luedde
Journal:  Hepatology       Date:  2015-12-18       Impact factor: 17.425

5.  cIAP1-dependent TRAF2 degradation regulates the differentiation of monocytes into macrophages and their response to CD40 ligand.

Authors:  Alban Dupoux; Jessy Cartier; Séverine Cathelin; Rodolphe Filomenko; Eric Solary; Laurence Dubrez-Daloz
Journal:  Blood       Date:  2008-09-30       Impact factor: 22.113

Review 6.  Cell death and cell death responses in liver disease: mechanisms and clinical relevance.

Authors:  Tom Luedde; Neil Kaplowitz; Robert F Schwabe
Journal:  Gastroenterology       Date:  2014-07-18       Impact factor: 22.682

7.  Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure.

Authors:  Kenji Takemoto; Etsuro Hatano; Keiko Iwaisako; Masatoshi Takeiri; Naruto Noma; Saori Ohmae; Kan Toriguchi; Kazutaka Tanabe; Hirokazu Tanaka; Satoru Seo; Kojiro Taura; Keigo Machida; Norihiko Takeda; Shigehira Saji; Shinji Uemoto; Masataka Asagiri
Journal:  FEBS Open Bio       Date:  2014-09-06       Impact factor: 2.693

8.  RIPK1 protects from TNF-α-mediated liver damage during hepatitis.

Authors:  Aveline Filliol; Claire Piquet-Pellorce; Jacques Le Seyec; Muhammad Farooq; Valentine Genet; Catherine Lucas-Clerc; John Bertin; Peter J Gough; Marie-Thérèse Dimanche-Boitrel; Peter Vandenabeele; Mathieu Jm Bertrand; Michel Samson
Journal:  Cell Death Dis       Date:  2016-11-10       Impact factor: 8.469

9.  NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis.

Authors:  Vangelis Kondylis; Apostolos Polykratis; Hanno Ehlken; Laura Ochoa-Callejero; Beate Katharina Straub; Santosh Krishna-Subramanian; Trieu-My Van; Harald-Morten Curth; Nicole Heise; Falk Weih; Ulf Klein; Peter Schirmacher; Michelle Kelliher; Manolis Pasparakis
Journal:  Cancer Cell       Date:  2015-11-09       Impact factor: 31.743
  9 in total
  5 in total

Review 1.  Apoptosis and necroptosis in the liver: a matter of life and death.

Authors:  Robert F Schwabe; Tom Luedde
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2018-12       Impact factor: 46.802

Review 2.  Effects of BTK signalling in pathogenic microorganism infections.

Authors:  Bingjue Ye; Cheng Zhou; Huiting Guo; Min Zheng
Journal:  J Cell Mol Med       Date:  2019-08-08       Impact factor: 5.310

3.  JNK signaling prevents biliary cyst formation through a CASPASE-8-dependent function of RIPK1 during aging.

Authors:  Katrin Müller; Hanna Honcharova-Biletska; Christiane Koppe; Michèle Egger; Lap Kwan Chan; Anne T Schneider; Lena Küsgens; Friederike Böhm; Yannick Boege; Marc E Healy; Johannes Schmitt; Sarah Comtesse; Mirco Castoldi; Christian Preisinger; Marta Szydlowska; Enrico Focaccia; Nadine T Gaisa; Sven H Loosen; Simone Jörs; Frank Tacke; Christoph Roderburg; Verena Keitel; Johannes G Bode; Peter Boor; Roger J Davis; Thomas Longerich; Fabian Geisler; Mathias Heikenwalder; Achim Weber; Mihael Vucur; Tom Luedde
Journal:  Proc Natl Acad Sci U S A       Date:  2021-03-23       Impact factor: 11.205

4.  RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages.

Authors:  Liang Tao; Yuguo Yi; Yuxin Chen; Haibing Zhang; Pontus Orning; Egil Lien; Jiapeng Jie; Weigao Zhang; Qian Xu; Yang Li; Zhao Ding; Chao Wu; Qiurong Ding; Junsong Wang; Jianfa Zhang; Dan Weng
Journal:  Cell Death Differ       Date:  2020-11-18       Impact factor: 15.828

5.  PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis.

Authors:  Valentina C Sladky; Katja Knapp; Tamas G Szabo; Vincent Z Braun; Laura Bongiovanni; Hilda van den Bos; Diana Cj Spierings; Bart Westendorp; Ana Curinha; Tatjana Stojakovic; Hubert Scharnagl; Gerald Timelthaler; Kaoru Tsuchia; Matthias Pinter; Georg Semmler; Floris Foijer; Alain de Bruin; Thomas Reiberger; Nataliya Rohr-Udilova; Andreas Villunger
Journal:  EMBO Rep       Date:  2020-11-23       Impact factor: 9.071
  5 in total

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