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Literature DB >> 28616571

A time out for CENP-A.

Abstract

Proper chromosome segregation relies on a functional centromere-kinetochore interface. We showed that chromatin containing CENtromere Protein A (CENP-A) is essential for centromere assembly, but dispensable for chromosome segregation in the presence of CENP-B-bound DNA sequences. This demonstrates the existence of two contact points between the DNA and the kinetochore to mediate successful chromosome segregation.

Entities: Gene

Keywords: Auxin; CENP-A; CENP-B; CENP-C; cancer; centromere; chromosome segregation; histone depletion; mitosis; protein degradation

Year: 2017 PMID： 28616571 PMCID： PMC5462523 DOI： 10.1080/23723556.2017.1293596

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

10 in total

1. The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface.

Authors: Kara L McKinley; Nikolina Sekulic; Lucie Y Guo; Tonia Tsinman; Ben E Black; Iain M Cheeseman
Journal: Mol Cell Date: 2015-11-19 Impact factor: 17.970

2. The human CENP-A centromeric nucleosome-associated complex.

Authors: Daniel R Foltz; Lars E T Jansen; Ben E Black; Aaron O Bailey; John R Yates; Don W Cleveland
Journal: Nat Cell Biol Date: 2006-04-16 Impact factor: 28.824

3. An auxin-based degron system for the rapid depletion of proteins in nonplant cells.

Authors: Kohei Nishimura; Tatsuo Fukagawa; Haruhiko Takisawa; Tatsuo Kakimoto; Masato Kanemaki
Journal: Nat Methods Date: 2009-11-15 Impact factor: 28.547

4. Inducible, reversible system for the rapid and complete degradation of proteins in mammalian cells.

Authors: Andrew J Holland; Daniele Fachinetti; Joo Seok Han; Don W Cleveland
Journal: Proc Natl Acad Sci U S A Date: 2012-11-12 Impact factor: 11.205

5. Insights from biochemical reconstitution into the architecture of human kinetochores.

Authors: John R Weir; Alex C Faesen; Kerstin Klare; Arsen Petrovic; Federica Basilico; Josef Fischböck; Satyakrishna Pentakota; Jenny Keller; Marion E Pesenti; Dongqing Pan; Doro Vogt; Sabine Wohlgemuth; Franz Herzog; Andrea Musacchio
Journal: Nature Date: 2016-08-31 Impact factor: 49.962

2 in total

1. Ccp1-Ndc80 switch at the N terminus of CENP-T regulates kinetochore assembly.

Authors: Qianhua Dong; Xue-Lei Liu; Xiao-Hui Wang; Yu Zhao; Yu-Hang Chen; Fei Li
Journal: Proc Natl Acad Sci U S A Date: 2021-11-30 Impact factor: 11.205

Review 2. Cell cycle control of kinetochore assembly.

Authors: Qianhua Dong; Fei Li
Journal: Nucleus Date: 2022-12 Impact factor: 4.590

2 in total

A time out for CENP-A.

1. The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface.

2. The human CENP-A centromeric nucleosome-associated complex.

3. An auxin-based degron system for the rapid depletion of proteins in nonplant cells.

4. Inducible, reversible system for the rapid and complete degradation of proteins in mammalian cells.

5. Insights from biochemical reconstitution into the architecture of human kinetochores.

6. CENP-A Is Dispensable for Mitotic Centromere Function after Initial Centromere/Kinetochore Assembly.

7. DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function.

8. A two-step mechanism for epigenetic specification of centromere identity and function.

9. A unique chromatin complex occupies young α-satellite arrays of human centromeres.

Review 10. The centromere: chromatin foundation for the kinetochore machinery.

1. Ccp1-Ndc80 switch at the N terminus of CENP-T regulates kinetochore assembly.

Review 2. Cell cycle control of kinetochore assembly.