Aysun Coskunoglu1, Seda Orenay-Boyacioglu2, Artuner Deveci3, Mustafa Bayam4, Ece Onur5, Arzu Onan5, Fethi S Cam1. 1. Department of Medical Genetics, Faculty of Medicine, Celal Bayar University, Manisa, Turkey. 2. Department of Medical Genetics, Faculty of Medicine, Adnan Menderes University, Efeler, Aydin, Turkey. 3. Department of Psychiatry, Faculty of Medicine, Celal Bayar University, Manisa, Turkey. 4. Department of Otorhinolaryngology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey. 5. Department of Medical Biochemistry, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
Abstract
BACKGROUND: Brain-derived neurotrophic factor (BDNF) gene polymorphisms are associated with abnormalities in regulation of BDNF secretion. Studies also linked BDNF polymorphisms with changes in brainstem auditory-evoked response test results. Furthermore, BDNF levels are reduced in tinnitus, psychiatric disorders, depression, dysthymic disorder that may be associated with stress, conversion disorder, and suicide attempts due to crises of life. For this purpose, we investigated whether there is any role of BDNF changes in the pathophysiology of tinnitus. MATERIALS AND METHODS: In this study, we examined the possible effects of BDNF variants in individuals diagnosed with tinnitus for more than 3 months. Fifty-two tinnitus subjects between the ages of 18 and 55, and 42 years healthy control subjects in the same age group, who were free of any otorhinolaryngology and systemic disease, were selected for examination. The intensity of tinnitus and depression was measured using the tinnitus handicap inventory, and the differential diagnosis of psychiatric diagnoses made using the Structured Clinical Interview for Fourth Edition of Mental Disorders. BDNF gene polymorphism was analyzed in the genomic deoxyribonucleic acid (DNA) samples extracted from the venous blood, and the serum levels of BDNF were measured. One-way analysis of variance and Chi-squared tests were applied. RESULTS: Serum BDNF level was found lower in the tinnitus patients than controls, and it appeared that there is no correlation between BDNF gene polymorphism and tinnitus. CONCLUSIONS: This study suggests neurotrophic factors such as BDNF may have a role in tinnitus etiology. Future studies with larger sample size may be required to further confirm our results.
BACKGROUND:Brain-derived neurotrophic factor (BDNF) gene polymorphisms are associated with abnormalities in regulation of BDNF secretion. Studies also linked BDNF polymorphisms with changes in brainstem auditory-evoked response test results. Furthermore, BDNF levels are reduced in tinnitus, psychiatric disorders, depression, dysthymic disorder that may be associated with stress, conversion disorder, and suicide attempts due to crises of life. For this purpose, we investigated whether there is any role of BDNF changes in the pathophysiology of tinnitus. MATERIALS AND METHODS: In this study, we examined the possible effects of BDNF variants in individuals diagnosed with tinnitus for more than 3 months. Fifty-two tinnitus subjects between the ages of 18 and 55, and 42 years healthy control subjects in the same age group, who were free of any otorhinolaryngology and systemic disease, were selected for examination. The intensity of tinnitus and depression was measured using the tinnitus handicap inventory, and the differential diagnosis of psychiatric diagnoses made using the Structured Clinical Interview for Fourth Edition of Mental Disorders. BDNF gene polymorphism was analyzed in the genomic deoxyribonucleic acid (DNA) samples extracted from the venous blood, and the serum levels of BDNF were measured. One-way analysis of variance and Chi-squared tests were applied. RESULTS: Serum BDNF level was found lower in the tinnituspatients than controls, and it appeared that there is no correlation between BDNF gene polymorphism and tinnitus. CONCLUSIONS: This study suggests neurotrophic factors such as BDNF may have a role in tinnitus etiology. Future studies with larger sample size may be required to further confirm our results.
Authors: Haroon I Sheikh; Elizabeth P Hayden; Katie R Kryski; Heather J Smith; Shiva M Singh Journal: Psychiatr Genet Date: 2010-06 Impact factor: 2.458
Authors: Tao Pan; Richard S Tyler; Haihong Ji; Claudia Coelho; Anne K Gehringer; Stephanie A Gogel Journal: Int J Audiol Date: 2009-05 Impact factor: 2.117
Authors: Carol A Bauer; Jeremy G Turner; Donald M Caspary; Kristin S Myers; Thomas J Brozoski Journal: J Neurosci Res Date: 2008-08-15 Impact factor: 4.164
Authors: F Miyajima; W Ollier; A Mayes; A Jackson; N Thacker; P Rabbitt; N Pendleton; M Horan; A Payton Journal: Genes Brain Behav Date: 2007-10-31 Impact factor: 3.449
Authors: Rodrigo Urbina-Varela; María Inés Soto-Espinoza; Romina Vargas; Luis Quiñones; Andrea Del Campo Journal: Aging Dis Date: 2020-12-01 Impact factor: 6.745
Authors: Helena R R Wells; Fatin N Zainul Abidin; Maxim B Freidin; Frances M K Williams; Sally J Dawson Journal: Sci Rep Date: 2021-03-19 Impact factor: 4.379
Authors: Jo-Eun Jeong; Sekye Jeon; Jae Sang Han; Eun Young Cho; Kyung Sue Hong; Shi Nae Park; Jung Jin Kim Journal: Psychiatry Investig Date: 2021-03-10 Impact factor: 2.505
Authors: Laura Basso; Benjamin Boecking; Patrick Neff; Petra Brueggemann; Eva M J Peters; Birgit Mazurek Journal: Sci Rep Date: 2022-02-04 Impact factor: 4.379