Robert G Kowalski1, Juliet K Haarbauer-Krupa2, Jeneita M Bell2, John D Corrigan2, Flora M Hammond2, Michel T Torbey2, Melissa C Hofmann2, Kristen Dams-O'Connor2, A Cate Miller2, Gale G Whiteneck2. 1. From the Research Department, Craig Hospital, Englewood, CO (R.G.K., M.C.H., G.G.W.); Division of Unintentional Injury Prevention, Centers for Disease Control and Prevention, Atlanta, GA (J.K.H.-K., J.M.B.); Department of Physical Medicine and Rehabilitation (J.D.C.), and Departments of Neuroscience, Neurology and Neurological Surgery, Division of Cerebrovascular Disease and Neurocritical Care (M.T.T.), Ohio State University Wexner Medical Center, Columbus; Department of Physical Medicine and Rehabilitation, Indiana University School of Medicine, Indianapolis (F.M.H.); Department of Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (K.D.-O.); and National Institute on Disability, Independent Living, and Rehabilitation Research, Administration for Community Living, U.S. Department of Health and Human Services (A.C.M.). rkowalski@craighospital.org. 2. From the Research Department, Craig Hospital, Englewood, CO (R.G.K., M.C.H., G.G.W.); Division of Unintentional Injury Prevention, Centers for Disease Control and Prevention, Atlanta, GA (J.K.H.-K., J.M.B.); Department of Physical Medicine and Rehabilitation (J.D.C.), and Departments of Neuroscience, Neurology and Neurological Surgery, Division of Cerebrovascular Disease and Neurocritical Care (M.T.T.), Ohio State University Wexner Medical Center, Columbus; Department of Physical Medicine and Rehabilitation, Indiana University School of Medicine, Indianapolis (F.M.H.); Department of Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (K.D.-O.); and National Institute on Disability, Independent Living, and Rehabilitation Research, Administration for Community Living, U.S. Department of Health and Human Services (A.C.M.).
Abstract
BACKGROUND AND PURPOSE: Traumatic brain injury (TBI) leads to nearly 300 000 annual US hospitalizations and increased lifetime risk of acute ischemic stroke (AIS). Occurrence of AIS immediately after TBI has not been well characterized. We evaluated AIS acutely after TBI and its impact on outcome. METHODS: A prospective database of moderate to severe TBI survivors, admitted to inpatient rehabilitation at 22 Traumatic Brain Injury Model Systems centers and their referring acute-care hospitals, was analyzed. Outcome measures were AIS incidence, duration of posttraumatic amnesia, Functional Independence Measure, and Disability Rating Scale, at rehabilitation discharge. RESULTS: Between October 1, 2007, and March 31, 2015, 6488 patients with TBI were enrolled in the Traumatic Brain Injury Model Systems National Database. One hundred and fifty-nine (2.5%) patients had a concurrent AIS, and among these, median age was 40 years. AIS was associated with intracranial mass effect and carotid or vertebral artery dissection. High-velocity events more commonly caused TBI with dissection. AIS predicted poorer outcome by all measures, accounting for a 13.3-point reduction in Functional Independence Measure total score (95% confidence interval, -16.8 to -9.7; P<0.001), a 1.9-point increase in Disability Rating Scale (95% confidence interval, 1.3-2.5; P<0.001), and an 18.3-day increase in posttraumatic amnesia duration (95% confidence interval, 13.1-23.4; P<0.001). CONCLUSIONS: Ischemic stroke is observed acutely in 2.5% of moderate to severe TBI survivors and predicts worse functional and cognitive outcome. Half of TBI patients with AIS were aged ≤40 years, and AIS patients more often had cervical dissection. Vigilance for AIS is warranted acutely after TBI, particularly after high-velocity events.
BACKGROUND AND PURPOSE:Traumatic brain injury (TBI) leads to nearly 300 000 annual US hospitalizations and increased lifetime risk of acute ischemic stroke (AIS). Occurrence of AIS immediately after TBI has not been well characterized. We evaluated AIS acutely after TBI and its impact on outcome. METHODS: A prospective database of moderate to severe TBI survivors, admitted to inpatient rehabilitation at 22 Traumatic Brain Injury Model Systems centers and their referring acute-care hospitals, was analyzed. Outcome measures were AIS incidence, duration of posttraumatic amnesia, Functional Independence Measure, and Disability Rating Scale, at rehabilitation discharge. RESULTS: Between October 1, 2007, and March 31, 2015, 6488 patients with TBI were enrolled in the Traumatic Brain Injury Model Systems National Database. One hundred and fifty-nine (2.5%) patients had a concurrent AIS, and among these, median age was 40 years. AIS was associated with intracranial mass effect and carotid or vertebral artery dissection. High-velocity events more commonly caused TBI with dissection. AIS predicted poorer outcome by all measures, accounting for a 13.3-point reduction in Functional Independence Measure total score (95% confidence interval, -16.8 to -9.7; P<0.001), a 1.9-point increase in Disability Rating Scale (95% confidence interval, 1.3-2.5; P<0.001), and an 18.3-day increase in posttraumatic amnesia duration (95% confidence interval, 13.1-23.4; P<0.001). CONCLUSIONS:Ischemic stroke is observed acutely in 2.5% of moderate to severe TBI survivors and predicts worse functional and cognitive outcome. Half of TBI patients with AIS were aged ≤40 years, and AIS patients more often had cervical dissection. Vigilance for AIS is warranted acutely after TBI, particularly after high-velocity events.
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