Literature DB >> 28610943

Stretch-induced actomyosin contraction in epithelial tubes: Mechanotransduction pathways for tubular homeostasis.

Kriti Sethi1, Erin J Cram2, Ronen Zaidel-Bar3.   

Abstract

Many tissues in our body have a tubular shape and are constantly exposed to various stresses. Luminal pressure imposes tension on the epithelial and myoepithelial or smooth muscle cells surrounding the lumen of the tubes. Contractile forces generated by actomyosin assemblies within these cells oppose the luminal pressure and must be calibrated to maintain tube diameter homeostasis and tissue integrity. In this review, we discuss mechanotransduction pathways that can lead from sensation of cell stretch to activation of actomyosin contractility, providing rapid mechanochemical feedback for proper tubular tissue function.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Calcium; Contractility; Epithelial tubes; Integrin signaling; Mechanotransduction; RhoA; Smooth muscle; Stretch

Mesh:

Substances:

Year:  2017        PMID: 28610943      PMCID: PMC5659885          DOI: 10.1016/j.semcdb.2017.05.014

Source DB:  PubMed          Journal:  Semin Cell Dev Biol        ISSN: 1084-9521            Impact factor:   7.727


  101 in total

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