Cardiac and hepatic acyl-CoA and acylcarnitine hydrolase activities in clofibrate-fed rabbits.

Catalase activity in the heart of male rabbits was 21% of that found in the liver; clofibrate feeding (0.3% w/w for 10 days) resulted in an 80% increase in both cardiac and hepatic catalase activities. Fatty acyl-CoA oxidase activity in control heart was 11% of that found in control liver; this peroxisomal activity did not increase subsequent to clofibrate feeding. Only acyl-CoA hydrolase activity in the cardiac supernatant was elevated by clofibrate feeding. Acylcarnitine hydrolase activity was increased significantly in the homogenate, extract and supernatant of both heart and liver from the clofibrate-fed rabbit. Clofibrate feeding increased CoASH and carnitine tissue levels in heart and liver.