Literature DB >> 2861015

Comparative actions of GABA and acetylcholine on the Xenopus laevis lateral line.

R P Bobbin, S C Bledsoe, S Winbery, G Ceasar, G L Jenison.   

Abstract

The effects of GABA, acetylcholine and carbachol on the spontaneous activity of afferent nerve fibers in the lateral line of Xenopus laevis are characterized. Atropine and bicuculline were also tested on drug- and water motion-evoked activity. GABA (0.019-1.25 mM) suppressed and both acetylcholine (1.25-80 microM) and carbachol (1.25-40 microM) increased spontaneous activity. These actions were blocked by bicuculline (100 microM) and atropine (4 microM) respectively. Atropine (20 microM) and bicuculline (100 microM) had no effect on water motion-evoked activity. The results characterize actions of GABA and acetylcholine not previously described and provide evidence that does not support the hypothesis that GABA or acetylcholine are the afferent transmitter.

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Year:  1985        PMID： 2861015     DOI： 10.1016/0742-8413(85)90062-3

Source DB:  PubMed          Journal:  Comp Biochem Physiol C        ISSN： 0742-8413


  6 in total

1.  Pharmacology of acetylcholine-mediated cell signaling in the lateral line organ following efferent stimulation.

Authors:  Rosie Dawkins; Sarah L Keller; William F Sewell
Journal:  J Neurophysiol       Date:  2004-12-22       Impact factor: 2.714

2.  A subpopulation of outer hair cells possessing GABA receptors with tonotopic organization.

Authors:  P K Plinkert; H Möhler; H P Zenner
Journal:  Arch Otorhinolaryngol       Date:  1989

3.  Muscarinic Acetylcholine Receptors and M-Currents Underlie Efferent-Mediated Slow Excitation in Calyx-Bearing Vestibular Afferents.

Authors:  J Chris Holt; Paivi M Jordan; Anna Lysakowski; Amit Shah; Kathy Barsz; Donatella Contini
Journal:  J Neurosci       Date:  2017-01-16       Impact factor: 6.167

4.  Functional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or delta.

Authors:  Stéphane F Maison; Thomas W Rosahl; Gregg E Homanics; M Charles Liberman
Journal:  J Neurosci       Date:  2006-10-04       Impact factor: 6.167

5.  Neuropharmacological analysis of synaptic transmission in the Lorenzinian ampulla of the skate Raja clavata.

Authors:  G Akoev; G N Andrianov; T Szabo; B Bromm
Journal:  J Comp Physiol A       Date:  1991-06       Impact factor: 1.836

Review 6.  A review of efferent cholinergic synaptic transmission in the vestibular periphery and its functional implications.

Authors:  L A Poppi; J C Holt; R Lim; A M Brichta
Journal:  J Neurophysiol       Date:  2019-12-04       Impact factor: 2.714
  6 in total

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