Aude Pavilla1,2,3, Giulio Gambarota4,5, Alessandro Arrigo6, Mehdi Mejdoubi6, Régis Duvauferrier6, Hervé Saint-Jalmes4,5,7. 1. INSERM, UMR 1099, 35000, Rennes, France. aude.pavilla@gmail.com. 2. Université de Rennes 1, LTSI, 35000, Rennes, France. aude.pavilla@gmail.com. 3. Department of Neuroradiology, Pierre-Zobda-Quitman Hospital, University Hospital of Martinique, Fort-de- France, Martinique, France. aude.pavilla@gmail.com. 4. INSERM, UMR 1099, 35000, Rennes, France. 5. Université de Rennes 1, LTSI, 35000, Rennes, France. 6. Department of Neuroradiology, Pierre-Zobda-Quitman Hospital, University Hospital of Martinique, Fort-de- France, Martinique, France. 7. CRLCC, Centre Eugène Marquis, 35000, Rennes, France.
Abstract
OBJECTIVES: The objectives were to investigate the diffusional kurtosis imaging (DKI) incorporation into the intravoxel incoherent motion (IVIM) model for measurements of cerebral hypoperfusion in healthy subjects. MATERIALS AND METHODS: Eight healthy subjects underwent a hyperventilation challenge with a 4-min diffusion weighted imaging protocol, using 8 b values chosen with the Cramer-Rao Lower Bound optimization approach. Four regions of interest in gray matter (GM) were analyzed with the DKI-IVIM model and the bi-exponential IVIM model, for normoventilation and hyperventilation conditions. RESULTS: A significant reduction in the perfusion fraction (f) and in the product fD* of the perfusion fraction with the pseudodiffusion coefficient (D*) was found with the DKI-IVIM model, during the hyperventilation challenge. In the cerebellum GM, the percentage changes were f: -43.7 ± 40.1, p = 0.011 and fD*: -50.6 ± 32.1, p = 0.011; in thalamus GM, f: -47.7 ± 34.7, p = 0.012 and fD*: -47.2 ± 48.7, p = 0.040. In comparison, using the bi-exponential IVIM model, only a significant decrease in the parameter fD* was observed for the same regions of interest. In frontal-GM and posterior-GM, the reduction in f and fD* did not reach statistical significance, either with DKI-IVIM or the bi-exponential IVIM model. CONCLUSION: When compared to the bi-exponential IVIM model, the DKI-IVIM model displays a higher sensitivity to detect changes in perfusion induced by the hyperventilation condition.
OBJECTIVES: The objectives were to investigate the diffusional kurtosis imaging (DKI) incorporation into the intravoxel incoherent motion (IVIM) model for measurements of cerebral hypoperfusion in healthy subjects. MATERIALS AND METHODS: Eight healthy subjects underwent a hyperventilation challenge with a 4-min diffusion weighted imaging protocol, using 8 b values chosen with the Cramer-Rao Lower Bound optimization approach. Four regions of interest in gray matter (GM) were analyzed with the DKI-IVIM model and the bi-exponential IVIM model, for normoventilation and hyperventilation conditions. RESULTS: A significant reduction in the perfusion fraction (f) and in the product fD* of the perfusion fraction with the pseudodiffusion coefficient (D*) was found with the DKI-IVIM model, during the hyperventilation challenge. In the cerebellum GM, the percentage changes were f: -43.7 ± 40.1, p = 0.011 and fD*: -50.6 ± 32.1, p = 0.011; in thalamus GM, f: -47.7 ± 34.7, p = 0.012 and fD*: -47.2 ± 48.7, p = 0.040. In comparison, using the bi-exponential IVIM model, only a significant decrease in the parameter fD* was observed for the same regions of interest. In frontal-GM and posterior-GM, the reduction in f and fD* did not reach statistical significance, either with DKI-IVIM or the bi-exponential IVIM model. CONCLUSION: When compared to the bi-exponential IVIM model, the DKI-IVIM model displays a higher sensitivity to detect changes in perfusion induced by the hyperventilation condition.
Authors: Kevin M Bennett; Kathleen M Schmainda; Raoqiong Tong Bennett; Daniel B Rowe; Hanbing Lu; James S Hyde Journal: Magn Reson Med Date: 2003-10 Impact factor: 4.668
Authors: Jing Yuan; David Ka Wai Yeung; Greta S P Mok; Kunwar S Bhatia; Yi-Xiang J Wang; Anil T Ahuja; Ann D King Journal: PLoS One Date: 2014-01-23 Impact factor: 3.240