Literature DB >> 28607018

Antibiotic-Mediated Modulations of Outer Membrane Vesicles in Enterohemorrhagic Escherichia coli O104:H4 and O157:H7.

Andreas Bauwens1, Lisa Kunsmann1, Helge Karch1,2, Alexander Mellmann1,2, Martina Bielaszewska3.   

Abstract

Ciprofloxacin, meropenem, fosfomycin, and polymyxin B strongly increase production of outer membrane vesicles (OMVs) in Escherichia coli O104:H4 and O157:H7. Ciprofloxacin also upregulates OMV-associated Shiga toxin 2a, the major virulence factor of these pathogens, whereas the other antibiotics increase OMV production without the toxin. These two effects might worsen the clinical outcome of infections caused by Shiga toxin-producing E. coli Our data support the existing recommendations to avoid antibiotics for treatment of these infections.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  Shiga toxins; antibiotics; enterohemorrhagic E. coli; hemolytic uremic syndrome; outer membrane vesicles

Mesh：

Substances：

Year:  2017        PMID： 28607018      PMCID： PMC5571282          DOI： 10.1128/AAC.00937-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  28 in total

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Authors:  Helge Karch; Phillip I Tarr; Martina Bielaszewska
Journal:  Int J Med Microbiol       Date:  2005-10       Impact factor: 3.473

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7.  Vesiculation from Pseudomonas aeruginosa under SOS.

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8.  Release of outer membrane vesicles by Gram-negative bacteria is a novel envelope stress response.

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Journal:  Mol Microbiol       Date:  2006-12-05       Impact factor: 3.501

9.  The effect of imipenem and diffusible signaling factors on the secretion of outer membrane vesicles and associated Ax21 proteins in Stenotrophomonas maltophilia.

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10.  Virulence from vesicles: Novel mechanisms of host cell injury by Escherichia coli O104:H4 outbreak strain.

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Journal:  Sci Rep       Date:  2015-08-18       Impact factor: 4.379
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5.  Significant increase in the secretion of extracellular vesicles and antibiotics resistance from methicillin-resistant Staphylococcus aureus induced by ampicillin stress.

Authors:  Si Won Kim; Jong-Su Seo; Seong Bin Park; Ae Rin Lee; Jung Seok Lee; Jae Wook Jung; Jin Hong Chun; Jassy Mary S Lazarte; Jaesung Kim; Jong-Hwan Kim; Jong-Wook Song; Chris Franco; Wei Zhang; Min Woo Ha; Seung-Mann Paek; Myunghwan Jung; Tae Sung Jung
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Review 6.  Membrane Vesicle Production as a Bacterial Defense Against Stress.

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7.  Carboxy-Terminal Processing Protease Controls Production of Outer Membrane Vesicles and Biofilm in Acinetobacter baumannii.

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Review 8.  Valid Presumption of Shiga Toxin-Mediated Damage of Developing Erythrocytes in EHEC-Associated Hemolytic Uremic Syndrome.

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9.  Evidence of sequestration of triclabendazole and associated metabolites by extracellular vesicles of Fasciola hepatica.

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Review 10.  Secretion and Delivery of Intestinal Pathogenic Escherichia coli Virulence Factors via Outer Membrane Vesicles.

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