M D Crema1, D T Felson2, A Guermazi3, M C Nevitt4, J Niu2, J A Lynch4, M D Marra5, J Torner6, C E Lewis7, F W Roemer8. 1. Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, Saint-Antoine Hospital, University Paris VI, Paris, France. Electronic address: michelcrema@gmail.com. 2. Clinical Epidemiology Research and Training Unit, Boston University, Boston, MA, USA. 3. Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, Boston, MA, USA. 4. Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, USA. 5. Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, Saint-Antoine Hospital, University Paris VI, Paris, France. 6. University of Iowa, Iowa City, IA, USA. 7. University of Alabama, Birmingham, AL, USA. 8. Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, University of Erlangen, Erlangen, Germany.
Abstract
OBJECTIVE: To assess the associations of atrophic tibiofemoral osteoarthritis (OA) with progression of radiographic joint space narrowing (JSN) and magnetic resonance imaging (MRI)-defined progression of cartilage damage. DESIGN: Participants of the Multicenter Osteoarthritis (MOST) Study with available radiographic and MRI assessments at baseline and 30 months were included. The atrophic OA phenotype was defined as Osteoarthritis Research Society International (OARSI) grades 1 or 2 for JSN and grade 0 for osteophytes. Based on MRI, atrophic OA was defined as tibiofemoral (TF) cartilage damage grades ≥3 in at least 2 of 10 subregions with absent or tiny osteophytes in all TF subregions. Progression of JSN and cartilage loss on MRI, was defined as (1) no, (2) slow, and (3) fast progression. Co-variance and logistic regression with generalized estimated equations were performed to assess the association of atrophic knee OA with any progression, compared to non-atrophic OA knees. RESULTS: A total of 476 knees from 432 participants were included. There were 50 (10.5%) knees with atrophic OA using the radiographic definition, and 16 (3.4%) knees with atrophic OA using MRI definition. Non-atrophic OA knees more commonly exhibited fast progression of JSN and cartilage damage. Logistic regression showed that the atrophic phenotype of knee OA was associated with a decreased likelihood of progression of JSN and cartilage loss. CONCLUSION: In this sample, the atrophic phenotype of knee OA was associated with a decreased likelihood of progression of JSN and cartilage loss compared to the non-atrophic knee OA phenotype.
OBJECTIVE: To assess the associations of atrophic tibiofemoral osteoarthritis (OA) with progression of radiographic joint space narrowing (JSN) and magnetic resonance imaging (MRI)-defined progression of cartilage damage. DESIGN:Participants of the Multicenter Osteoarthritis (MOST) Study with available radiographic and MRI assessments at baseline and 30 months were included. The atrophic OA phenotype was defined as Osteoarthritis Research Society International (OARSI) grades 1 or 2 for JSN and grade 0 for osteophytes. Based on MRI, atrophic OA was defined as tibiofemoral (TF) cartilage damage grades ≥3 in at least 2 of 10 subregions with absent or tiny osteophytes in all TF subregions. Progression of JSN and cartilage loss on MRI, was defined as (1) no, (2) slow, and (3) fast progression. Co-variance and logistic regression with generalized estimated equations were performed to assess the association of atrophic knee OA with any progression, compared to non-atrophic OA knees. RESULTS: A total of 476 knees from 432 participants were included. There were 50 (10.5%) knees with atrophic OA using the radiographic definition, and 16 (3.4%) knees with atrophic OA using MRI definition. Non-atrophic OA knees more commonly exhibited fast progression of JSN and cartilage damage. Logistic regression showed that the atrophic phenotype of knee OA was associated with a decreased likelihood of progression of JSN and cartilage loss. CONCLUSION: In this sample, the atrophic phenotype of knee OA was associated with a decreased likelihood of progression of JSN and cartilage loss compared to the non-atrophic knee OA phenotype.
Authors: Manish Kothari; Ali Guermazi; Gabriele von Ingersleben; Yves Miaux; Martine Sieffert; Jon E Block; Randall Stevens; Charles G Peterfy Journal: Eur Radiol Date: 2004-05-19 Impact factor: 5.315
Authors: M D Crema; M C Nevitt; A Guermazi; D T Felson; K Wang; J A Lynch; M D Marra; J Torner; C E Lewis; F W Roemer Journal: Osteoarthritis Cartilage Date: 2014-10 Impact factor: 6.576
Authors: F W Roemer; A Guermazi; M K Javaid; J A Lynch; J Niu; Y Zhang; D T Felson; C E Lewis; J Torner; M C Nevitt Journal: Ann Rheum Dis Date: 2008-10-01 Impact factor: 19.103
Authors: C G Peterfy; A Guermazi; S Zaim; P F J Tirman; Y Miaux; D White; M Kothari; Y Lu; K Fye; S Zhao; H K Genant Journal: Osteoarthritis Cartilage Date: 2004-03 Impact factor: 6.576
Authors: Frank W Roemer; Yuqing Zhang; Jingbo Niu; John A Lynch; Michel D Crema; Monica D Marra; Michael C Nevitt; David T Felson; Laura B Hughes; George Y El-Khoury; Martin Englund; Ali Guermazi Journal: Radiology Date: 2009-07-27 Impact factor: 11.105
Authors: F W Roemer; J Collins; C K Kwoh; M J Hannon; T Neogi; D T Felson; D J Hunter; J A Lynch; A Guermazi Journal: Osteoarthritis Cartilage Date: 2019-09-09 Impact factor: 6.576
Authors: Frank W Roemer; Mohamed Jarraya; Jamie E Collins; C Kent Kwoh; Daichi Hayashi; David J Hunter; Ali Guermazi Journal: Skeletal Radiol Date: 2022-09-26 Impact factor: 2.128