Gayani C Liyanage1, Sarath Lekamwasam2, Thilak P Weerarathna2, Chandrani E Liyanage3. 1. Department of Pharmacology, Faculty of Medicine, University of Ruhuna, Sri Lanka. Electronic address: gayanicl@yahoo.com. 2. Department of Medicine, Faculty of Medicine, University of Ruhuna, Sri Lanka. 3. Nuclear Medicine Unit, Faculty of Medicine, University of Ruhuna, Sri Lanka.
Abstract
AIMS: Aim of this study was to determine the effect of high dose vitamin D given to patients with early diabetic renal disease on systolic and diastolic blood pressure, total cholesterol (TC), low-density lipoproteins (LDL), triglycerides (TG) and high density lipoproteins (HDL) in a randomized controlled trial MATERIALS AND METHOD:Patients with early diabetic nephropathy were recruited. Selected patients were allocated to two groups by Block randomization method. Treatment group received 50,000 IU of vitamin D3 intramuscularly and the control group was given an equal volume of distilled water (0.25mL) monthly for six months. Blood and urine were collected at the baseline for biochemical analyses and blood pressure was measured. After six months all the measurements done at the baseline were repeated. RESULTS: Of 155 patients invited, 85 were randomly assigned to two groups. No significant differences were found between treatment and control groups at the baseline. Vitamin D therapy significantly reduced DBP, total cholesterol and LDL but the between group differences were not significant. There was an increase in HDL cholesterol level in the treatment group while there was no change in the control group Between groups difference was significant (P=<0.001). CONCLUSIONS: There was a significant improvement of serum HDL level with six months therapy of high dose vitamin D in patients with early diabetic nephropathy.
RCT Entities:
AIMS: Aim of this study was to determine the effect of high dose vitamin D given to patients with early diabetic renal disease on systolic and diastolic blood pressure, total cholesterol (TC), low-density lipoproteins (LDL), triglycerides (TG) and high density lipoproteins (HDL) in a randomized controlled trial MATERIALS AND METHOD:Patients with early diabetic nephropathy were recruited. Selected patients were allocated to two groups by Block randomization method. Treatment group received 50,000 IU of vitamin D3 intramuscularly and the control group was given an equal volume of distilled water (0.25mL) monthly for six months. Blood and urine were collected at the baseline for biochemical analyses and blood pressure was measured. After six months all the measurements done at the baseline were repeated. RESULTS: Of 155 patients invited, 85 were randomly assigned to two groups. No significant differences were found between treatment and control groups at the baseline. Vitamin D therapy significantly reduced DBP, total cholesterol and LDL but the between group differences were not significant. There was an increase in HDL cholesterol level in the treatment group while there was no change in the control group Between groups difference was significant (P=<0.001). CONCLUSIONS: There was a significant improvement of serum HDL level with six months therapy of high dose vitamin D in patients with early diabetic nephropathy.
Authors: João Soares Felício; Alana Ferreira de Oliveira; Amanda Soares Peixoto; Ana Carolina Contente Braga de Souza; João Felício Abrahão Neto; Franciane Trindade Cunha de Melo; Carolina Tavares Carvalho; Manuela Nascimento de Lemos; Sávio Diego Nascimento Cavalcante; Fabricio de Souza Resende; Márcia Costa Dos Santos; Ana Regina Motta; Luísa Corrêa Janaú; Elizabeth Sumi Yamada; Karem Miléo Felício Journal: Front Endocrinol (Lausanne) Date: 2017-08-14 Impact factor: 5.555