OBJECTIVE: To investigate the status of pubertal development in children born with assisted reproductive technology (ART). METHODS: A retrospective analysis was performed on the pubertal development data of children born with ART in Peking University Third Hospital from 1994 to 2003 (ART group). The data in the cross-sectional study "Reports on the Physical Fitness and Health Research of Chinese School Students in 2010" were used as a control. The age at menarche and the age at spermarche were compared between the two groups. The status of pubertal development in the overweight and obese children in the ART group was evaluated to investigate the correlation between pubertal development and body mass index (BMI). RESULTS: A total of 200 children born with ART were enrolled in this study, and 72 of them (41 males and 31 females) completed the survey (response rate=36.0%). In the ART group, the mean age at spermarche and the mean age at menarche were 13.9 years (95%CI: 13.7-14.3 years) and 12.2 years (95%CI: 11.8-12.6 years), respectively. There were no significant differences in the age at spermarche and the age at menarche between the ART and control groups (P>0.05). In the ART group, there were no significant differences in the age at spermarche and the age at menarche between the overweight and obese children and the normal weight children (P>0.05). There were also no significant differences in overweight rate and obesity rate between the children in the ART group and the adolescents in Beijing (P>0.05). In the ART group, there was no significant correlation between the age at spermarche or menarche and BMI (P>0.05). CONCLUSIONS: No delayed or precocious puberty is observed in children born with ART. This is consistent with the normal control data. And there is no significant correlation between pubertal development and BMI in children born with ART.
OBJECTIVE: To investigate the status of pubertal development in children born with assisted reproductive technology (ART). METHODS: A retrospective analysis was performed on the pubertal development data of children born with ART in Peking University Third Hospital from 1994 to 2003 (ART group). The data in the cross-sectional study "Reports on the Physical Fitness and Health Research of Chinese School Students in 2010" were used as a control. The age at menarche and the age at spermarche were compared between the two groups. The status of pubertal development in the overweight and obesechildren in the ART group was evaluated to investigate the correlation between pubertal development and body mass index (BMI). RESULTS: A total of 200 children born with ART were enrolled in this study, and 72 of them (41 males and 31 females) completed the survey (response rate=36.0%). In the ART group, the mean age at spermarche and the mean age at menarche were 13.9 years (95%CI: 13.7-14.3 years) and 12.2 years (95%CI: 11.8-12.6 years), respectively. There were no significant differences in the age at spermarche and the age at menarche between the ART and control groups (P>0.05). In the ART group, there were no significant differences in the age at spermarche and the age at menarche between the overweight and obesechildren and the normal weight children (P>0.05). There were also no significant differences in overweight rate and obesity rate between the children in the ART group and the adolescents in Beijing (P>0.05). In the ART group, there was no significant correlation between the age at spermarche or menarche and BMI (P>0.05). CONCLUSIONS: No delayed or precocious puberty is observed in children born with ART. This is consistent with the normal control data. And there is no significant correlation between pubertal development and BMI in children born with ART.
Authors: Hind A Beydoun; Nicholas Sicignano; May A Beydoun; Silvina Bocca; Laurel Stadtmauer; Sergio Oehninger Journal: Fertil Steril Date: 2010-06-13 Impact factor: 7.329
Authors: Manon Ceelen; Mirjam M van Weissenbruch; Jan P W Vermeiden; Flora E van Leeuwen; Henriette A Delemarre-van de Waal Journal: Hum Reprod Date: 2008-08-09 Impact factor: 6.918
Authors: John Rb Perry; Felix Day; Cathy E Elks; Patrick Sulem; Kari Stefansson; Joanne M Murabito; Ken K Ong; Deborah J Thompson; Teresa Ferreira; Chunyan He; Daniel I Chasman; Tõnu Esko; Gudmar Thorleifsson; Eva Albrecht; Wei Q Ang; Tanguy Corre; Diana L Cousminer; Bjarke Feenstra; Nora Franceschini; Andrea Ganna; Andrew D Johnson; Sanela Kjellqvist; Kathryn L Lunetta; George McMahon; Ilja M Nolte; Lavinia Paternoster; Eleonora Porcu; Albert V Smith; Lisette Stolk; Alexander Teumer; Natalia Tšernikova; Emmi Tikkanen; Sheila Ulivi; Erin K Wagner; Najaf Amin; Laura J Bierut; Enda M Byrne; Jouke-Jan Hottenga; Daniel L Koller; Massimo Mangino; Tune H Pers; Laura M Yerges-Armstrong; Jing Hua Zhao; Irene L Andrulis; Hoda Anton-Culver; Femke Atsma; Stefania Bandinelli; Matthias W Beckmann; Javier Benitez; Carl Blomqvist; Stig E Bojesen; Manjeet K Bolla; Bernardo Bonanni; Hiltrud Brauch; Hermann Brenner; Julie E Buring; Jenny Chang-Claude; Stephen Chanock; Jinhui Chen; Georgia Chenevix-Trench; J Margriet Collée; Fergus J Couch; David Couper; Andrea D Coveillo; Angela Cox; Kamila Czene; Adamo Pio D'adamo; George Davey Smith; Immaculata De Vivo; Ellen W Demerath; Joe Dennis; Peter Devilee; Aida K Dieffenbach; Alison M Dunning; Gudny Eiriksdottir; Johan G Eriksson; Peter A Fasching; Luigi Ferrucci; Dieter Flesch-Janys; Henrik Flyger; Tatiana Foroud; Lude Franke; Melissa E Garcia; Montserrat García-Closas; Frank Geller; Eco Ej de Geus; Graham G Giles; Daniel F Gudbjartsson; Vilmundur Gudnason; Pascal Guénel; Suiqun Guo; Per Hall; Ute Hamann; Robin Haring; Catharina A Hartman; Andrew C Heath; Albert Hofman; Maartje J Hooning; John L Hopper; Frank B Hu; David J Hunter; David Karasik; Douglas P Kiel; Julia A Knight; Veli-Matti Kosma; Zoltan Kutalik; Sandra Lai; Diether Lambrechts; Annika Lindblom; Reedik Mägi; Patrik K Magnusson; Arto Mannermaa; Nicholas G Martin; Gisli Masson; Patrick F McArdle; Wendy L McArdle; Mads Melbye; Kyriaki Michailidou; Evelin Mihailov; Lili Milani; Roger L Milne; Heli Nevanlinna; Patrick Neven; Ellen A Nohr; Albertine J Oldehinkel; Ben A Oostra; Aarno Palotie; Munro Peacock; Nancy L Pedersen; Paolo Peterlongo; Julian Peto; Paul Dp Pharoah; Dirkje S Postma; Anneli Pouta; Katri Pylkäs; Paolo Radice; Susan Ring; Fernando Rivadeneira; Antonietta Robino; Lynda M Rose; Anja Rudolph; Veikko Salomaa; Serena Sanna; David Schlessinger; Marjanka K Schmidt; Mellissa C Southey; Ulla Sovio; Meir J Stampfer; Doris Stöckl; Anna M Storniolo; Nicholas J Timpson; Jonathan Tyrer; Jenny A Visser; Peter Vollenweider; Henry Völzke; Gerard Waeber; Melanie Waldenberger; Henri Wallaschofski; Qin Wang; Gonneke Willemsen; Robert Winqvist; Bruce Hr Wolffenbuttel; Margaret J Wright; Dorret I Boomsma; Michael J Econs; Kay-Tee Khaw; Ruth Jf Loos; Mark I McCarthy; Grant W Montgomery; John P Rice; Elizabeth A Streeten; Unnur Thorsteinsdottir; Cornelia M van Duijn; Behrooz Z Alizadeh; Sven Bergmann; Eric Boerwinkle; Heather A Boyd; Laura Crisponi; Paolo Gasparini; Christian Gieger; Tamara B Harris; Erik Ingelsson; Marjo-Riitta Järvelin; Peter Kraft; Debbie Lawlor; Andres Metspalu; Craig E Pennell; Paul M Ridker; Harold Snieder; Thorkild Ia Sørensen; Tim D Spector; David P Strachan; André G Uitterlinden; Nicholas J Wareham; Elisabeth Widen; Marek Zygmunt; Anna Murray; Douglas F Easton Journal: Nature Date: 2014-07-23 Impact factor: 49.962