Literature DB >> 2860614

Effects of traumatic injury on dynorphin immunoreactivity in spinal cord.

B M Cox, C J Molineaux, T P Jacobs, J G Rosenberger, A I Faden.   

Abstract

Traumatic spinal cord injury in rats resulted in a significant eleation of dynorphin A immunoreactivity in spinal cord tissue at the level of, and below, the site of injury. [Leu5]enkephalin levels in the same tissue samples were not significantly altered following severe injury. Dynorphin A immunoreactivity was found in the fraction relatively enriched in synaptosomes after subcellular fractionation of spinal cord tissue. The dynorphin A content of this fraction was not significantly changed following injury, suggesting that dynorphin containing nerve terminals and axons are not severely damaged as a result of the injury.

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Year:  1985        PMID： 2860614     DOI： 10.1016/0143-4179(85)90082-4

Source DB:  PubMed          Journal:  Neuropeptides        ISSN： 0143-4179            Impact factor:   3.286


  8 in total

Review 1.  Central non-opioid physiological and pathophysiological effects of dynorphin A and related peptides.

Authors:  V K Shukla; S Lemaire
Journal:  J Psychiatry Neurosci       Date:  1992-09       Impact factor: 6.186

Review 2.  Pathobiology of dynorphins in trauma and disease.

Authors:  Kurt F Hauser; Jane V Aldrich; Kevin J Anderson; Georgy Bakalkin; MacDonald J Christie; Edward D Hall; Pamela E Knapp; Stephen W Scheff; Indrapal N Singh; Bryce Vissel; Amina S Woods; Tatiana Yakovleva; Toni S Shippenberg
Journal:  Front Biosci       Date:  2005-01-01

3.  Nor-Binaltorphimine Blocks the Adverse Effects of Morphine after Spinal Cord Injury.

Authors:  Miriam Aceves; Eric A Bancroft; Alejandro R Aceves; Michelle A Hook
Journal:  J Neurotrauma       Date:  2016-11-04       Impact factor: 5.269

4.  Dynorphin A (1-13) neurotoxicity in vitro: opioid and non-opioid mechanisms in mouse spinal cord neurons.

Authors:  K F Hauser; J K Foldes; C S Turbek
Journal:  Exp Neurol       Date:  1999-12       Impact factor: 5.330

5.  Antagonists of the kappa-opioid receptor enhance allodynia in rats and mice after sciatic nerve ligation.

Authors:  I Obara; J Mika; M K-H Schafer; B Przewlocka
Journal:  Br J Pharmacol       Date:  2003-09-01       Impact factor: 8.739

6.  Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance.

Authors:  Mei Xu; Michael Petraschka; Jay P McLaughlin; Ruth E Westenbroek; Marc G Caron; Robert J Lefkowitz; Traci A Czyzyk; John E Pintar; Gregory W Terman; Charles Chavkin
Journal:  J Neurosci       Date:  2004-05-12       Impact factor: 6.167

7.  Enhanced evoked excitatory transmitter release in experimental neuropathy requires descending facilitation.

Authors:  L R Gardell; T W Vanderah; S E Gardell; R Wang; M H Ossipov; J Lai; F Porreca
Journal:  J Neurosci       Date:  2003-09-10       Impact factor: 6.167

8.  Morphine-induced changes in the function of microglia and macrophages after acute spinal cord injury.

Authors:  Mabel N Terminel; Carla Bassil; Josephina Rau; Amanda Trevino; Cristina Ruiz; Robert Alaniz; Michelle A Hook
Journal:  BMC Neurosci       Date:  2022-10-10       Impact factor: 3.264
  8 in total

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