| Literature DB >> 2860594 |
M R Ruff, S M Wahl, S Mergenhagen, C B Pert.
Abstract
The opiate peptides, D-ala-D-leuenkephalin, beta-endorphin and dynorphin, [1-13] are potent stimulators of human mononuclear cell chemotaxis. Peak responses were observed in the range of 10(-8) - 10(-11)M with activity detectable at 10(-14)M. Morphine was without effect in this assay. Incubation of cells with (-) naloxone but not (+) naloxone completely blocked activity, supporting stereospecific opiate receptor-mediated chemotaxis. Opiates and other neuropeptides are discussed as components of a network whose purpose is to integrate brain and behavioral modalities with immune function.Entities:
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Year: 1985 PMID： 2860594 DOI： 10.1016/0143-4179(85)90029-0
Source DB: PubMed Journal: Neuropeptides ISSN： 0143-4179 Impact factor: 3.286